Overdose Risk

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Overdose Risk trials you may qualify for

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 5 trials

RecruitingPhase 2/3

NCT06633900

Naltrexone for Overdose Prevention

The goal of this clinical trial is to see if an injectable medicine called naltrexone can prevent fentanyl overdose deaths in people who use other drugs (cocain…

United States100 participantsStarted 2025-04-10

Treatment: IM naltrexone, Usual Care

RecruitingPhase 3

NCT07524972

Antenatal Magnesium Sulphate in High-Risk Preterm Patients

The goal of this clinical trial is to evaluate whether antenatal magnesium sulphate reduces the risk of cerebral palsy in infants born to women at high risk of…

Egypt138 participantsStarted 2026-05-01

Treatment: Magnesium sulfate, Placebo

RecruitingNot Applicable

NCT06806163

Machine-Learning Prediction and Reducing Overdoses With EHR Nudges

The goal of this cluster randomized clinical trial is to test a clinician-targeted behavioral nudge intervention in the Electronic Health Record (EHR) for patie…

United States1,350 participantsStarted 2025-03-10

Treatment: EHR-Embedded Elevated-Risk Flag, EHR-Embedded Elevated-Risk Flag with Behavioral Nudges

RecruitingNot Applicable

NCT07022717

A Universal Primary Care Based Intervention to Reduce Youth Overdose Risk

Adolescent (ages 10-19) overdose deaths are the third leading cause of pediatric death and continue to rise in the United States. Healthcare providers have regu…

United States24 participantsStarted 2025-08-25

Treatment: Brief youth overdose prevention education, Information about Naloxone

RecruitingNot Applicable

NCT05665179

Removing Barriers: Community Partnering for Innovative Solutions to the Opioid Crisis

The opioid epidemic has become one of America's deadliest crises, surpassing car crashes, firearms, and HIV/AIDS as a leading cause of death for Americans under…

United States800 participantsStarted 2021-12-23

Treatment: Removing Barriers to Recovery

All recent trials (33 shown)

Active — Not RecruitingNot Applicable

NCT05657106

Kentucky Outreach Service Kiosk (KyOSK): Reducing HIV, HCV, and Overdose Risk

This study will test the effectiveness, implementation outcomes, and cost effectiveness of a community-tailored, harm reduction kiosk in reducing HIV, hepatitis…

United States752 participantsStarted 2023-03-06

Treatment: Harm reduction kiosk

Not Yet RecruitingNot Applicable

NCT07179614

Kentucky Women's Justice Community Overdose Innovation Network - Phase II

This project continues our work with women in the Kentucky Women's Justice Community Overdose Innovation Network Phase II (WJCOIN-II) with the overall aim of re…

United States300 participantsStarted 2026-05-18

Treatment: Overdose Prevention Intervention Package (OPIP)

Overdose Risk

Trial phase breakdown

Trial status

Actively recruiting — 5 trials

Naltrexone for Overdose Prevention

Antenatal Magnesium Sulphate in High-Risk Preterm Patients

Machine-Learning Prediction and Reducing Overdoses With EHR Nudges

A Universal Primary Care Based Intervention to Reduce Youth Overdose Risk

Removing Barriers: Community Partnering for Innovative Solutions to the Opioid Crisis

All recent trials (33 shown)

Kentucky Outreach Service Kiosk (KyOSK): Reducing HIV, HCV, and Overdose Risk

Kentucky Women's Justice Community Overdose Innovation Network - Phase II

Trial phase breakdown

Trial status

Actively recruiting — 5 trials

Naltrexone for Overdose Prevention

Antenatal Magnesium Sulphate in High-Risk Preterm Patients

Machine-Learning Prediction and Reducing Overdoses With EHR Nudges

A Universal Primary Care Based Intervention to Reduce Youth Overdose Risk

Removing Barriers: Community Partnering for Innovative Solutions to the Opioid Crisis

All recent trials (33 shown)

Kentucky Outreach Service Kiosk (KyOSK): Reducing HIV, HCV, and Overdose Risk

Kentucky Women's Justice Community Overdose Innovation Network - Phase II

Patient and Caregiver Attitudes and Beliefs Regarding Prescription of Intranasal Naloxone Spray for Opioid Overdose

Developing and Evaluating a Machine-Learning Opioid Overdose Prediction & Risk-Stratification Tool in Primary Care

Trauma-informed Intervention to Reduce Substance Use and to Support Community Transition

Stimulant Overdose in the Medicaid Population: Who is at Risk, and When Are They at Risk

Smartphone Intervention for Overdose and COVID-19

The Impact of a Web-Based Naloxone Intervention Under Standing Orders to Patients Prescribed Chronic Opioid Therapy

Repeated-dose Brief Intervention to Reduce Overdose and Risk Behaviors Among Naloxone Recipients

Impact of Direct Outreach to Expand Access to Naloxone in the Context of Standing Orders

25OH Vitamin D Overdoses and Risk of Bronchopulmonary Dysplasia or Death

Maternal Risk Factors for Autism Spectrum Disorders: A Case-Control Approach

The Impact of Co-Dispensing Naloxone to Patients Prescribed Chronic Opioid Therapy

Extended-release Injectable Buprenorphine for Individuals at High Risk of Overdose

Risks and Benefits of Naloxone Prescribing

Project OOPEN: Opioid Overdose Prevention, Education and Intervention

Evolution of Psychoactive Substances Consumption in Connection With COVID-19 Containment

The OPT-IN Project

Addressing Overdose Risk Among Recently Incarcerated People Living With HIV/AIDS

Biomarkers, Blood Pressure, BIS: Risk Stratification/Management of Patients at Cardiac Risk in Major Noncardiac Surgery