CompletedNot Applicable

Repeated-dose Brief Intervention to Reduce Overdose and Risk Behaviors Among Naloxone Recipients

United States63 participantsStarted 2014-07

Plain-language summary

REBOOT is a pilot randomized trial of a repeated-dose brief intervention to reduce overdose and risk behaviors among naloxone recipients (REBOOT). It includes an established overdose education curriculum within an Informational-Motivation-Behavior (IMB) model. This study will test the feasibility of an efficacy trial of REBOOT vs treatment as usual (information and referrals) that will evaluate overdose events (non-fatal or death), drug use cessation, and overdose and HIV risk behaviors, among opioid-dependent persons who have previously overdosed and already received take-home naloxone (the opioid antagonist used to reverse overdose).

Who can participate

Age range18 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * age 18-65 years; * current opioid dependence by SCID * urine positive for opioids during screening, excluding prescribed agonist maintenance therapy * history of prior opioid overdose * previously received take-home naloxone * no serious illnesses likely to progress clinically during trial * able and willing to provide informed consent, provide locator information, communicate in English, adhere to visit schedule Exclusion Criteria: * suicidal ideation by concise health risk tracking (CHRT) * currently participating in another interventional research study that could possible impact the study's outcomes of interest * any condition that, in the Principal Investigator's judgment, interferes with safe study participation or adherence to study procedures

What they're measuring

Feasibility of a randomized trial with REBOOT

Timeframe: 16 months

Acceptability of REBOOT

Timeframe: 16 months

Influence of egocentric social network characteristics on overdose events and naloxone use

Timeframe: 16 months

Trial details

NCT IDNCT02093559

SponsorSan Francisco Department of Public Health

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2016-12

View on ClinicalTrials.gov More Opioid-Related Disorders trials

Plain-language summary

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.