Opioid-Induced Disorders

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Opioid-Induced Disorders trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 39 trials

RecruitingNot Applicable

NCT07573150

Pupillometry in Identifying Risk of Postoperative Opioid-induced Respiratory Depression in Children Undergoing Tonsillec…

This study will evaluate whether quantitative pupillometry measurements can be used to identify children at risk for postoperative opioid-induced respiratory de…

United States300 participantsStarted 2026-05-04

Treatment: Infrared Pupillometry

RecruitingPhase 4

NCT06429436

Vending Machine Naloxone Distribution for Your Community (VENDY)

Vending machines are an innovative strategy shown to increase access to naloxone, a medication used to reverse opioid overdose. The aim of this proposal is to s…

United States4,000 participantsStarted 2024-06-01

Treatment: VENDY

RecruitingPhase 1

NCT06967259

ENA-001 for Opioid Induced Respiratory Depression

This study is a Phase I clinical trial to assess the safety, tolerability, and pharmacokinetic (PK) and pharmacodynamic (PD) profiles with single intravenous (I…

United States36 participantsStarted 2025-05-14

Treatment: ENA-001, Placebo Comparator

RecruitingNot Applicable

NCT06954402

Resilience Among Individuals With Opioid Use Disorder

The goal of this clinical trial is to develop a human laboratory model of resilience in people with opioid use disorder (OUD). The investigators aim to learn if…

United States125 participantsStarted 2026-05-29

Treatment: Acute Stress Intervention (MAST-based), Non-Stress Intervention (NST-based)

RecruitingNot Applicable

NCT06104280

Medications for Opioid Use Disorder Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythms: Implica…

Opioid use disorder (OUD) is a treatable medical illness with three medications FDA approved for treatment. However, persons with OUD report significant sleep d…

United States200 participantsStarted 2025-01-06

Treatment: Post-Illumination Pupillary Response (PIPR), Polysomnography

RecruitingNot Applicable

NCT06821516

Comparison of Pain Relief Methods for Hip Surgery: A Study on Two Different Nerve Block Techniques

This prospective randomized comparative study aims to compare the analgesic efficacy of pericapsular nerve group block (PENG) and lumbar erector spinae plane bl…

Turkey (Türkiye)52 participantsStarted 2025-01-21

Treatment: Evaluation of the postoperative analgesic effectiveness of PENG block in participants undergoing total hip arthroplasty under spinal anesthesia, Evaluation of the postoperative analgesic effectiveness of lumbar erector spinae block in participants undergoing total hip arthroplasty under spinal anesthesia

All recent trials (100 shown)

SuspendedNot Applicable

NCT06577454

Measuring the Effects of Neurostimulation on Risky and Ambiguous Decision-Making Capacity in People With and Without Sub…

Background: The purpose of this study is to understand how a type of brain stimulation, transcranial magnetic stimulation (TMS), may help those who use opioids…

United States60 participantsStarted 2026-05-13

Treatment: TMS (MagVenture MagPro 100 with MagOption)

TerminatedPhase 4

NCT05118204

Randomized Trial of Buprenorphine Microdose Inductions During Hospitalization

Investigators will test a novel protocol for starting BUP (buprenorphine-naloxone) treatment. The BUP microdose induction protocol has participants start very l…

United States23 participantsStarted 2022-09-29

Treatment: BUP microdose induction, TAU

Opioid-Induced Disorders

Trial phase breakdown

Trial status

Actively recruiting — 39 trials

Pupillometry in Identifying Risk of Postoperative Opioid-induced Respiratory Depression in Children Undergoing Tonsillec…

Vending Machine Naloxone Distribution for Your Community (VENDY)

ENA-001 for Opioid Induced Respiratory Depression

Resilience Among Individuals With Opioid Use Disorder

Medications for Opioid Use Disorder Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythms: Implica…

Comparison of Pain Relief Methods for Hip Surgery: A Study on Two Different Nerve Block Techniques

All recent trials (100 shown)

Measuring the Effects of Neurostimulation on Risky and Ambiguous Decision-Making Capacity in People With and Without Sub…

Randomized Trial of Buprenorphine Microdose Inductions During Hospitalization

Trial phase breakdown

Trial status

Actively recruiting — 39 trials

Pupillometry in Identifying Risk of Postoperative Opioid-induced Respiratory Depression in Children Undergoing Tonsillec…

Vending Machine Naloxone Distribution for Your Community (VENDY)

ENA-001 for Opioid Induced Respiratory Depression

Resilience Among Individuals With Opioid Use Disorder

Medications for Opioid Use Disorder Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythms: Implica…

Comparison of Pain Relief Methods for Hip Surgery: A Study on Two Different Nerve Block Techniques

All recent trials (100 shown)

Measuring the Effects of Neurostimulation on Risky and Ambiguous Decision-Making Capacity in People With and Without Sub…

Randomized Trial of Buprenorphine Microdose Inductions During Hospitalization

Lofexidine Combined With Buprenorphine for Reducing Symptoms of PTSD and OU Relapse in Veterans

Buprenorphine Treatment: A Safe Alternative for Opioid Dependent Pain Patients

Improving Social Connectedness Through Digital Health to Enhance Recovery From OUD Among the Justice Involved Population

Development of an Interview-Informed Timeline Follow-Back (TLFB) for Opioid Use in the Era of Fentanyl

THRIVE: Culturally AdapTed Harm Reduction Intervention

Minds and Mentors Program- R33

Promoting HIV Risk Reduction Among People Who Inject Drugs: A Stepped Care Approach Using Contingency Management With Pr…

Kentucky Outreach Service Kiosk (KyOSK): Reducing HIV, HCV, and Overdose Risk

Improving Hospital-To-Methadone Clinic Connection Using Implementation Support for Patients With Opioid Use Disorder

Phase Ib/2a Drug-drug Interaction Study of a Combination of 45mg Dextromethorphan With 105 mg Bupropion

Simplified HCV Integrated Management Model in Methadone Clinics in Ukraine

Addressing Risk Through Community Treatment for Infectious Disease and Opioid Use Disorder Now (ACTION) Among Justice-in…

Behavioral Effects of Drugs (Inpatient): 43 (Opioids, Cocaine, n-Acetylcysteine)

Extended Release Naltrexone Versus Extended Release Buprenorphine With Individuals Leaving Jail

Intervening With Opioid-Dependent MothersMothers and Infants

Counseling for Harm Reduction and Retention in Medication-assisted Treatment - Cherokee Nation

Local Participatory Systems Dynamics to Increase Reach of Evidence Based Addiction and Mental Health Care

Computer Based Treatment for Cognitive Behavioral Therapy and Cooperative Pain Education and Self-Management