The Remote Methadone Ingestion Surveillance Trial (RMIST) will explore a potential method of methadone ingestion surveillance that may mitigate patient safety risks of take-home methadone treatment regimens while minimizing the risk of diversion and evaluating the acceptability and feasibility of these monitoring methods. The method utilizes an innovative existing technology.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Be male or female, 18-65 years of age
* Currently receiving methadone maintenance treatment (MMT) for the treatment of opioid use disorder (OUD)
* Currently receiving a take-home methadone regimen of no more than three days per week (with or without COVID-19 exceptions)
* Possess an internet-connected computer or smartphone with a front facing camera.
Exclusion Criteria:
* Drug overdose requiring hospitalization within the last 12 months
* Currently or soon to be in jail or prison; currently on probation; currently in any inpatient overnight facility as required by court of law or have pending legal action or other situation that could prevent participation in the study or in any study activities
* Pregnant women
* Serious psychiatric disorders that would interfere with study participation as determined by the study site Medical Clinician
* Any participant that, according to the study team, may find it difficult to adhere to study procedures (e.g., no internet access, etc.) or are unable to operate the web-based platform for remote methadone ingestion
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Methadone Treatment Adherence as Measured by the Number of Time-stamped Medication Consumption Events (MCE)
Timeframe: Day 2 to Day 20
2
Platform Usability as Measured by Number of Self-reported Instances Participants Need Assistance.
Timeframe: Day 2 to Day 20
3
Methadone Treatment Adherence as Measured by the Number of Time-stamped Missed Detection Events (MDE).
Timeframe: Day 2 to Day 20
Trial details
NCT IDNCT05259501
SponsorUniversity of Texas Southwestern Medical Center