Mitral Valve Prolapse

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Mitral Valve Prolapse trials you may qualify for

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 14 trials

RecruitingNot Applicable

NCT06378996

Arrhythmic Mitral Valve Prolapse Detection Using Long-term Ambulatory Rhythm Monitoring

Mitral valve prolapse (MVP) affects up to 3% of the general population and a small subset of patients is at risk for ventricular arrhythmias. This subgroup is r…

Belgium60 participantsStarted 2024-05-01

Treatment: 14-day rhythm monitoring

RecruitingNot Applicable

NCT05051033

Percutaneous or Surgical Repair In Mitral Prolapse And Regurgitation for ≥60 Year-olds (PRIMARY)

This is a prospective, multicenter, open-label, randomized trial comparing mitral valve (MV) transcatheter edge-to-edge repair (TEER) to surgical repair (1:1 ra…

United States450 participantsStarted 2022-02-21

Treatment: Mitral valve repair, Transcatheter edge-to-edge repair

RecruitingNot Applicable

NCT07384871

AI-Based Shape and Function Analysis of Mitral Valve Prolapse Using 3D Ultrasound

This study aims to develop and validate a fully automated imaging and modeling pipeline for the analysis of mitral valve prolapse (MVP) using real-time three-di…

Italy150 participantsStarted 2025-05-26

RecruitingNot Applicable

NCT06341166

Multiparametric SCores for Prediction of Myocardial fIbrosis in Patients With MITral vAlve pRolapse

This is a multicenter, observational prospective and retrospective study which aims are: 1) to compute a scoring model potentially predictive for the diagnosis…

Italy300 participantsStarted 2023-06-19

RecruitingNot Applicable

NCT06255457

Ventricular Arrhythmias in Patients Undergoing Mitral Valve Surgery

Study objectives: * To assess the impact of mitral valve surgery for mitral regurgitation on ventricular arrhythmic burden and surrogate markers of fibrosis in…

Sweden90 participantsStarted 2024-02-21

Treatment: Mitral valve surgery

RecruitingNot Applicable

NCT07103733

PRIMARY Ancillary Substudy

The PRIMARY trial (NCT05051033), which compares mitral valve repair (MVr) to transcatheter-edge-to-edge-repair (TEER), offers a platform for conducting mechanis…

United States250 participantsStarted 2023-10-16

Treatment: Cardiac Magnetic Resonance Imaging, ZioPatch Monitoring

All recent trials (57 shown)

Active — Not RecruitingNot Applicable

NCT07366723

The Role of cardIac magNeTic rEsonance in surGical Decision Making in Patients With Severe pRimAry miTral rEgurgitation

Mitral regurgitation (MR) is the second most frequent valvular heart disease and the second most frequent indication for valve surgery in Europe. The managemen…

Italy260 participantsStarted 2025-12-01

Treatment: mitral valve surgery, Clinical Follow up

CompletedNot Applicable

NCT06436573

Mitro-annular Disjunction in Cardiac Magnetic Resonance

Mitral annular disjunction (MAD) is an abnormal atrial displacement of the mitral valve leaflet hinge point. MAD is gaining clinical importance for several stud…

Italy4,000 participantsStarted 2024-05-15

Mitral Valve Prolapse

Trial phase breakdown

Trial status

Actively recruiting — 14 trials

Arrhythmic Mitral Valve Prolapse Detection Using Long-term Ambulatory Rhythm Monitoring

Percutaneous or Surgical Repair In Mitral Prolapse And Regurgitation for ≥60 Year-olds (PRIMARY)

AI-Based Shape and Function Analysis of Mitral Valve Prolapse Using 3D Ultrasound

Multiparametric SCores for Prediction of Myocardial fIbrosis in Patients With MITral vAlve pRolapse

Ventricular Arrhythmias in Patients Undergoing Mitral Valve Surgery

PRIMARY Ancillary Substudy

All recent trials (57 shown)

The Role of cardIac magNeTic rEsonance in surGical Decision Making in Patients With Severe pRimAry miTral rEgurgitation

Mitro-annular Disjunction in Cardiac Magnetic Resonance

Trial phase breakdown

Trial status

Actively recruiting — 14 trials

Arrhythmic Mitral Valve Prolapse Detection Using Long-term Ambulatory Rhythm Monitoring

Percutaneous or Surgical Repair In Mitral Prolapse And Regurgitation for ≥60 Year-olds (PRIMARY)

AI-Based Shape and Function Analysis of Mitral Valve Prolapse Using 3D Ultrasound

Multiparametric SCores for Prediction of Myocardial fIbrosis in Patients With MITral vAlve pRolapse

Ventricular Arrhythmias in Patients Undergoing Mitral Valve Surgery

PRIMARY Ancillary Substudy

All recent trials (57 shown)

The Role of cardIac magNeTic rEsonance in surGical Decision Making in Patients With Severe pRimAry miTral rEgurgitation

Mitro-annular Disjunction in Cardiac Magnetic Resonance

Korea VHD Echo Study: Surveillance of Aortic, Mitral & Tricuspid Patients - Insights From Real-world Practice

Triangular Exclusion Technique in Isolated Posterior Mitral Valve Leaflet Prolapse for Mitral Valve Repair

A Study of Mitral Annular Disjunction in Mitral Valve Prolapse Patients and Arrhythmia Risk

Impact of Preoperative Myocardial Fibrosis Related to Mitral Valve Prolapse on Postoperative Left Ventricular Remodeling

Observational Registry on the HARPOON Device

CE Mark Study for the Harpoon Medical Device in Poland

Safety and Early Feasibility Study of the Harpoon Medical Device (EFS)

CE Mark Study for the Harpoon Medical Device

Genetic Basis of Mitral Valve Prolapse

Operative Mitral Valve Reconstruction in Functional mv Insufficiency With Reduced Systolic Ventricle Function

Long Term Results of Surgical and Percutaneous Double Orefices Mitral Repair in Patient With p2 Prolapse Causing Degener…

Mitral Valve Prolapse, Arrhythmias and Mitral Valve Surgery

ChordArt System for Mitral Regurgitation

European FIH Study - NeoChord Transcatheter Mitral Repair System for Symptomatic Mitral Regurgitation

Myocardial Characterization of Arrhythmogenic Mitral Valve Prolapse (STAMP: STretch and Myocardial Characterization in A…

Determinants of the Progression and Outcome of Mitral Regurgitation

Genetic and Phenotypic Characteristics of Mitral Valve Prolapse

Erector Spinae Plane Block for Minimally Invasive Mitral Valve Surgery