Ketosis, Metabolic

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Ketosis, Metabolic trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 31 trials

RecruitingNot Applicable

NCT07227363

Symptoms of Polycystic Ovarian Syndrome Ameliorated by Keto-Adaptation Pilot

The SPARK- Pilot study (Symptoms of PCOS Ameliorated by Responses to Keto-adaptation) is a 12-week clinical trial at The Ohio State University designed to explo…

United States40 participantsStarted 2026-12-01

Treatment: Ketogenic diet, Exogenous Ketone Supplement

RecruitingNot Applicable

NCT06044935

Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate

Background: At least 30% of Americans have fatty liver disease. This means that they store too much fat in the liver. At the moment lifestyle changes are the o…

United States100 participantsStarted 2024-01-08

Treatment: Standard Diet, Ketogenic Diet

RecruitingNot Applicable

NCT06373016

Use of Ketosis in Modulating Metabolic Pathways in Bipolar Disorder

The goal of this clinical trial is to test how specific components of diet affect brain function and behavior for individuals with bipolar. The main question it…

United States100 participantsStarted 2024-01-26

Treatment: Glucose, Ketones

RecruitingPhase 4

NCT07527156

Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure

This study will evaluate the feasibility and safety of achieving therapeutic concentrations of beta-hydroxybutyrate using continuous infusion of D-beta-hydroxyb…

Czechia12 participantsStarted 2026-04-04

Treatment: Ketone Monoester (KE)

RecruitingEarly Phase 1

NCT05057806

SGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research Plan

The study team will examine the effects of SGLT2i (and SGLT2i-induced increases in plasma ketone concentrations) on skeletal muscle and cardiac ketone uptake, s…

United States30 participantsStarted 2021-01-13

Treatment: Empagliflozin 25 MG, Placebo

RecruitingNot Applicable

NCT06078683

Effects of Ketone Ester Consumption on Exercise Tolerance and Cardiac Function

This study is being done to evaluate how a ketone ester (KE) supplement affects heart function and health in people with diabetes compared to a placebo suppleme…

United States30 participantsStarted 2023-06-06

Treatment: Ketone Ester Acute, Placebo Acute

All recent trials (100 shown)

Not Yet RecruitingNot Applicable

NCT07576374

Specificities of Atypical Non AutoImmune Diabetes (ANAID) in the French West Indies

Genetics variants could be involved in atypical non-autoimmune diabetes revealed by ketoacidosis. The objective of this research will be to determine the relati…

Guadeloupe118 participantsStarted 2026-06

Not Yet RecruitingPhase 2/3

NCT06807918

Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder

This is a randomized, double-blind, crossover trial to evaluate the immediate effects of a nutritional ketone supplement, Kenotic compared to placebo on brain f…

United States60 participantsStarted 2026-06

Treatment: Kenetik, magnetic resonance imaging scan

Ketosis, Metabolic

Trial phase breakdown

Trial status

Actively recruiting — 31 trials

Symptoms of Polycystic Ovarian Syndrome Ameliorated by Keto-Adaptation Pilot

Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate

Use of Ketosis in Modulating Metabolic Pathways in Bipolar Disorder

Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure

SGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research Plan

Effects of Ketone Ester Consumption on Exercise Tolerance and Cardiac Function

All recent trials (100 shown)

Specificities of Atypical Non AutoImmune Diabetes (ANAID) in the French West Indies

Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder

Trial phase breakdown

Trial status

Actively recruiting — 31 trials

Symptoms of Polycystic Ovarian Syndrome Ameliorated by Keto-Adaptation Pilot

Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate

Use of Ketosis in Modulating Metabolic Pathways in Bipolar Disorder

Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure

SGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research Plan

Effects of Ketone Ester Consumption on Exercise Tolerance and Cardiac Function

All recent trials (100 shown)

Specificities of Atypical Non AutoImmune Diabetes (ANAID) in the French West Indies

Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder

Ketones in Heart Failure With Reduced Ejection Fraction

Exogenous Ketones and Appetite

Assessment of BHB Concentration Agreement Among Sampling Locations and the Impact of Ketosis on EPO, and More

A Medium Chain Triglyceride Intervention for Patients With Alzheimer Disease

Modeling Ketosis-Prone Diabetes Remission Via Diverse Mechanisms of Glucotoxicity

Effect of Nutritional Ketosis on Alcohol Metabolism

Effects of Ketone Supplementation on Acute Alcohol Withdrawal

Exogenous Ketone Supplementation in ICU Delirium

Therapeutic Education in Very Young Children With Diabetes Mellitus

Low-CArbohydrate Diet and SGLT2-INhibitOr to Achieve Moderate Ketosis in Healthy Volunteers

Exogenous Ketosis and Muscle Protein Synthesis During Exercise Recovery

Ketones for Opioid Craving

Impact of Clinical Nursing Guideline on Outcomes of Children With Diabetic Ketoacidosis.

Continuous Glucose Monitoring Using a New Subcutaneous Insulin Protocol for Mild to Moderate Diabetic Ketoacidosis

The Metabolic Effects of β-hydroxybutyrate on Working Skeletal Muscle

FAM (Follower, Action Plan, and Remote Monitoring) Intervention to Reduce Severe Hyperglycemia in Adults With Type 1 Dia…

Hemodynamic Effects of Ketone Esters in Patients With Sepsis Induced Cardiomyopathy

A Multi-Disciplinary Technology-Based Care for Diabetic Ketoacidosis in Patients With Type 1 Diabetes