RecruitingPhase 4

Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure

Czechia12 participantsStarted 2026-04-04

Plain-language summary

This study will evaluate the feasibility and safety of achieving therapeutic concentrations of beta-hydroxybutyrate using continuous infusion of D-beta-hydroxybutyrate monoester administered via a nasogastric tube in patients with acutely decompensated heart failure with reduced left ventricular ejection fraction.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * LVEF \<35% * Acute heart failure with low cardiac output syndrome or cardiogenic shock Exclusion Criteria: * Severe liver failure * Severe acidosis * Inability to insert nasogastric tube * Gastric paralysis / ileus * Repeated vomiting * Severe hypokalemia

What they're measuring

Proportion of time within the target concentration range

Timeframe: 36 hours

Trial details

NCT IDNCT07527156

SponsorInstitute for Clinical and Experimental Medicine

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2027-03-31

Contact for this trial

Marek Sramko, MD, PhD

+420776246127 marek.sramko@ikem.cz

View on ClinicalTrials.gov More Acute Heart Failure (AHF) trials