Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure (NCT07527156) | Clinical Trial Compass
RecruitingPhase 4
Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure
Czechia12 participantsStarted 2026-04-04
Plain-language summary
This study will evaluate the feasibility and safety of achieving therapeutic concentrations of beta-hydroxybutyrate using continuous infusion of D-beta-hydroxybutyrate monoester administered via a nasogastric tube in patients with acutely decompensated heart failure with reduced left ventricular ejection fraction.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* LVEF \<35%
* Acute heart failure with low cardiac output syndrome or cardiogenic shock
Exclusion Criteria:
* Severe liver failure
* Severe acidosis
* Inability to insert nasogastric tube
* Gastric paralysis / ileus
* Repeated vomiting
* Severe hypokalemia
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial uses a nasogastric tube to deliver ketones continuously — how long would I likely need that tube in place, and what does that mean for my day-to-day comfort and mobility while hospitalized?
2Since this is a Phase 4 trial, does that mean ketone treatment has already been tested for safety in earlier studies, and what do we currently know about its effects in people with acute heart failure or cardiogenic shock specifically?
3The trial is measuring how consistently ketone levels stay within a target range — what happens if my levels go too high or too low during the infusion, and how closely would I be monitored?
4Given that I'm dealing with decompensated heart failure, would standard treatments like IV diuretics or other medications already used for acute heart failure be a better first step before considering this trial?
5What is it about my specific situation — whether it's the severity of my heart failure or risk of cardiogenic shock — that would make me a good or poor candidate for a study like this one?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Proportion of time within the target concentration range
Timeframe: 36 hours
Trial details
NCT IDNCT07527156
SponsorInstitute for Clinical and Experimental Medicine