CompletedNot Applicable

The Metabolic Effects of β-hydroxybutyrate on Working Skeletal Muscle

Denmark25 participantsStarted 2022-12-22

Plain-language summary

The goal of this clinical trial is to test ketone bodies in healthy elderly and young individuals. The main question it aims to answer are: • Do ketone bodies improve skeletal muscle function? Participants will ingest a ketone monoester and skeletal muscle function will then be evaluated by: * Special magnetic imaging techniques * Intravenous infusion of tracer-marked nutrients * Performance tests on a ergometer bike and in a dynamometer Researchers will compare the outcomes between within the young and elderly groups and between the young and the elderly group to investigate if age has an effect on the outcomes.

Who can participate

Age range20 Years – 85 Years

SexMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Male 20-25 years old (n = 12) OR male 65-85 years old (n = 12) * BMI range: 19 to 27 * Stable weight (\< 5% change over last 6 months) * Less than 3 x 60 min of structured exercise per week. Exclusion Criteria: * Medication that affect energy metabolism. * Non-MR-compatible metals or electric devices in the body. * Anaemia or bleeding disorders. * Heart, lung or other disease that affects the subjects ability to exercise. * Smoking. * Drug abuse. * Lack of compliance. * Known allergy towards local anaesthetics. * Any condition that the principal investigator considers unsuitable for the subject's ability to complete the study.

What they're measuring

Work efficiency

Timeframe: Over 60 minutes on each of the two experimental days.

Trial details

NCT IDNCT05732909

SponsorUniversity of Aarhus

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-01-10

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