Distal Cholangiocarcinoma

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Distal Cholangiocarcinoma trials you may qualify for

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 3 trials

RecruitingPhase 1

NCT05285358

Pressurized Intraperitoneal Aerosolized Nab-Paclitaxel in Combination With Gemcitabine and Cisplatin for the Treatment o…

This phase I trial studies the side effects of pressurized intraperitoneal aerosolized chemotherapy (PIPAC) nab-paclitaxel in combination with gemcitabine and c…

United States12 participantsStarted 2022-09-19

Treatment: Cisplatin, Gemcitabine

RecruitingNot Applicable

NCT07328607

Outcomes After Laparoscopic Versus Open Pancreaticoduodenectomy

This is a monocentric, prospective, randomized controlled trial comparing the safety and efficacy of laparoscopic pancreaticoduodenectomy (LPD) versus open panc…

Egypt90 participantsStarted 2026-01-17

Treatment: Open Pancreaticoduodenectomy, Laparoscopic Pancreaticoduodenectomy

RecruitingNot Applicable

NCT06801899

ToPanc Trial: Survival After Total Versus Partial Pancreaticoduodenectomy for Adenocarcinoma of the Pancreatic Head, Dis…

The goal of this clinical trial is to learn if total removal of the pancreas is a preferable alternative to partial removal in patients with cancer of the pancr…

Switzerland170 participantsStarted 2025-05-12

Treatment: Total pancreatectomy (TP), Partial pancreaticoduodenectomy (PD)

All recent trials (36 shown)

Active — Not RecruitingPhase 2

NCT05564403

Study of Chemotherapy, With or Without Binimetinib in Advanced Biliary Tract Cancers in 2nd Line Setting (A ComboMATCH T…

This phase II ComboMATCH treatment trial compares the usual treatment of modified leucovorin, fluorouracil and oxaliplatin (mFOLFOX6) chemotherapy to using bini…

United States66 participantsStarted 2024-02-09

Treatment: Binimetinib, Biopsy Procedure

Active — Not RecruitingPhase 1

NCT04491942

Testing the Addition of an Anti-cancer Drug, BAY 1895344, to the Usual Chemotherapy Treatment (Cisplatin, or Cisplatin a…

This phase I trial identifies the best dose, possible benefits and/or side effects of BAY 1895344 in combination with chemotherapy in treating patients with sol…

United States74 participantsStarted 2021-08-25

Treatment: Cisplatin, Elimusertib

Distal Cholangiocarcinoma

Trial phase breakdown

Trial status

Actively recruiting — 3 trials

Pressurized Intraperitoneal Aerosolized Nab-Paclitaxel in Combination With Gemcitabine and Cisplatin for the Treatment o…

Outcomes After Laparoscopic Versus Open Pancreaticoduodenectomy

ToPanc Trial: Survival After Total Versus Partial Pancreaticoduodenectomy for Adenocarcinoma of the Pancreatic Head, Dis…

All recent trials (36 shown)

Study of Chemotherapy, With or Without Binimetinib in Advanced Biliary Tract Cancers in 2nd Line Setting (A ComboMATCH T…

Testing the Addition of an Anti-cancer Drug, BAY 1895344, to the Usual Chemotherapy Treatment (Cisplatin, or Cisplatin a…

Trial phase breakdown

Trial status

Actively recruiting — 3 trials

Pressurized Intraperitoneal Aerosolized Nab-Paclitaxel in Combination With Gemcitabine and Cisplatin for the Treatment o…

Outcomes After Laparoscopic Versus Open Pancreaticoduodenectomy

ToPanc Trial: Survival After Total Versus Partial Pancreaticoduodenectomy for Adenocarcinoma of the Pancreatic Head, Dis…

All recent trials (36 shown)

Study of Chemotherapy, With or Without Binimetinib in Advanced Biliary Tract Cancers in 2nd Line Setting (A ComboMATCH T…

Testing the Addition of an Anti-cancer Drug, BAY 1895344, to the Usual Chemotherapy Treatment (Cisplatin, or Cisplatin a…

Rilvegostomig + Chemotherapy as Adjuvant Therapy for Biliary Tract Cancer After Resection (ARTEMIDE-Biliary01)

Gemcitabine Hydrochloride and Cisplatin With or Without Nab-Paclitaxel in Treating Patients With Newly Diagnosed Advance…

Treatment of Distal Malignant Biliary Obstruction by Uncovered, Partially Covered, or Fully Covered Metal Stents

Feasibility Study of Multi-Platform Profiling of Resected Biliary Tract Cancer

First-line Treatment for Unresectable Locally Advanced Distal Cholangiocarcinoma Combining Radiotherapy and HAIC

Testing A New Combination of Anti-cancer Immune Therapies, Atezolizumab and CDX-1127 (Varlilumab) With or Without the Ad…

Role of Proton Pump Inhibitors on the Postoperative Course Following Pancreaticoduodenectomy

Immunotherapy With Durva and Treme With or Without Capecitabine in Adjuvant Treatment for Biliary Tract Cancer

Neoadjuvant Gemcitabine and Cisplatin in Combination With Perioperative Pembrolizumab Versus Upfront Surgery for Patient…

Toripalimab Combined With Capecitabine as Postoperative Adjuvant Therapy for Patients With Resectable Advanced Extrahepa…

Role of Adjuvant Chemotherapy in Distal Cholangiocarcinoma

Recurrence After Whipple's (RAW) Study

PCI Treatment/Gemcitabine & Chemotherapy vs Chemotherapy Alone in Patients With Inoperable Extrahepatic Bile Duct Cancer

Trifluridine/Tipiracil and Irinotecan for the Treatment of Advanced Refractory Biliary Tract Cancer

EUS-guided Choledochoduodenostomy for Primary Drainage of Malignant Distal Biliary Obstruction

Comparing NUC-1031 Plus Cisplatin to Gemcitabine Plus Cisplatin in Patients With Advanced Biliary Tract Cancer

Feasibility of Radiotherapy and Concomitant Gemcitabine and Oxaliplatin in Locally Advanced Pancreatic Cancer and Distal…

Preoperative Radiotherapy in Patients at High Risk of Postoperative Pancreatic Fistula After Pancreatoduodenectomy