CIN2

Clinical trial pipeline · Data from ClinicalTrials.gov

See which CIN2 trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 21 trials

RecruitingPhase 2

NCT07454915

PVX4 for the Treatment of Human Papilloma Virus (HPV)16+ Cervical Dysplasia

The purpose of this Phase 2 study is to compare the effects of administering the PVX4 combination device biologic product (pBI-4 DNA vaccine via electroporation…

United States, Taiwan138 participantsStarted 2026-04-01

Treatment: PVX4 Combination Product, Placebo Control

RecruitingNot Applicable

NCT07550010

Digital Telecytology for Triage of HPV-Positive Women in Cameroon

This study evaluates the diagnostic accuracy and feasibility of a same-day cervical cancer screening strategy using HPV self-sampling followed by digital telecy…

Cameroon1,800 participantsStarted 2025-09-08

Treatment: HPV testing (self-sampling), Digital telecytology

RecruitingNot Applicable

NCT07480902

Comparison Between Liquid-Based Cytology And Molecular Screening For Detecting Precursor Lesions and Cervical Cancer

This study compares how effective is the molecular screening (a blood test) using Pap smear as reference, that is, a comparison of these tests abilities to dete…

Mexico558 participantsStarted 2026-02-03

Treatment: Physical examination, Liquid-based cytology

RecruitingPhase 2

NCT04712851

Pembrolizumab for the Treatment of Cervical Intraepithelial Neoplasia

This phase II trial studies the effect of pembrolizumab on cervical intraepithelial neoplasia. Immunotherapy with monoclonal antibodies, such as pembrolizumab,…

United States25 participantsStarted 2021-06-30

Treatment: Pembrolizumab

RecruitingNot Applicable

NCT06979180

A Clinical Trial to Investigate the Safety and Efficacy of Papillex® on Abnormal Cervical Cells Caused by HPV.

The goal of this clinical trial is to investigate the safety and efficacy of Papillex® on the regression of abnormal cervical cells caused by HPV in women with…

Canada60 participantsStarted 2026-03

Treatment: Papillex®, Placebo

RecruitingNot Applicable

NCT06147388

Regression of Cervical Precancerous Lesions and Associated Risk Factors

The aim of this study is to assess the extent of histopathological regression of severe cervical precancerous lesions (CIN 2 and CIN 3); evaluate the proportion…

Czechia300 participantsStarted 2022-09-01

Treatment: Colposcopy

All recent trials (100 shown)

Not Yet RecruitingPhase 2

NCT07545746

Adjuvant 5-Fluorouracil Following Thermal Ablation to Improve HPV Treatment Outcomes in Women With HIV in Kenya

This randomized, placebo-controlled trial will evaluate self-administered 5-fluorouracil (5FU) to improve human papillomavirus (HPV) clearance after thermal abl…

Kenya140 participantsStarted 2026-05

Treatment: 5% 5-fluorouracil Topical Cream, Placebo Cream

CompletedNot Applicable

NCT04185389

Long-Term Follow-Up of HPV FOCAL Participants

This FOCAL follow-up study aims to assess the long-term effectiveness and safety of primary HPV testing for cervical cancer screening. A cohort of participants…

Canada1,710 participantsStarted 2020-09-30

Treatment: HPV and cytology co-testing (via Liquid based collection device)

CIN2

Trial phase breakdown

Trial status

Actively recruiting — 21 trials

PVX4 for the Treatment of Human Papilloma Virus (HPV)16+ Cervical Dysplasia

Digital Telecytology for Triage of HPV-Positive Women in Cameroon

Comparison Between Liquid-Based Cytology And Molecular Screening For Detecting Precursor Lesions and Cervical Cancer

Pembrolizumab for the Treatment of Cervical Intraepithelial Neoplasia

A Clinical Trial to Investigate the Safety and Efficacy of Papillex® on Abnormal Cervical Cells Caused by HPV.

Regression of Cervical Precancerous Lesions and Associated Risk Factors

All recent trials (100 shown)

Adjuvant 5-Fluorouracil Following Thermal Ablation to Improve HPV Treatment Outcomes in Women With HIV in Kenya

Long-Term Follow-Up of HPV FOCAL Participants

Trial phase breakdown

Trial status

Actively recruiting — 21 trials

PVX4 for the Treatment of Human Papilloma Virus (HPV)16+ Cervical Dysplasia

Digital Telecytology for Triage of HPV-Positive Women in Cameroon

Comparison Between Liquid-Based Cytology And Molecular Screening For Detecting Precursor Lesions and Cervical Cancer

Pembrolizumab for the Treatment of Cervical Intraepithelial Neoplasia

A Clinical Trial to Investigate the Safety and Efficacy of Papillex® on Abnormal Cervical Cells Caused by HPV.

Regression of Cervical Precancerous Lesions and Associated Risk Factors

All recent trials (100 shown)

Adjuvant 5-Fluorouracil Following Thermal Ablation to Improve HPV Treatment Outcomes in Women With HIV in Kenya

Long-Term Follow-Up of HPV FOCAL Participants

Assessing Administration of pBI-11 Via Electroporation for the Treatment of Patients With HPV16/18+

The Selfie Study- Assessing Novel Markers for Cervical Cancer Screening From Self-collected Samples

Comparison Of Cytology And Molecular Screening For Detecting Cervical Reactive Cellular Changes In General Population

Acceptability and Feasibility of Combination Treatment for Cervical Precancer Among South African Women Living With HIV

Multicenter Prospective Non-randomized Controlled Study of Ella Photodynamic Therapy for Cervical HSIL/CIN2

Empowering Women - Shared Decision Making in Managing Cervical Precancer

Cervical Intraepithelial Neoplasm (CIN) in Women (Gardasil) (V501-015)

Safety and Efficacy of Oral Artesunate for Pre-cervical Cancer

Extended VALidation of HUman Papillomavirus Assays and Collection DEvices for HPV Testing on Self-samples

Comparison of Cervical CIN II/III Treatment Outcomes With Thermal Ablation Device

Topical Fluorouracil and Imiquimod in Treating Patients With High-Grade Cervical Intraepithelial Neoplasia

An Innovative Treatment for Cervical Precancer (UH3)

The Adjuvant Effect of HPV Vaccination on Recurrence of Cervical Precancer or Carcinoma in Women Undergoing Conization

Effectiveness of Cervical Screening in HPV Vaccinated Women

Effectiveness of Cervical Screening in Unvaccinated, Herd Effect Protected Women (HPV400)

REVEAL 2 Trial (Evaluation of VGX-3100 and Electroporation for the Treatment of Cervical HSIL)

5-fluorouracil Following Cervical Intraepithelial Neoplasia Treatment Among HIV-positive Women in East Africa

ALA-PDT in Patients With CIN2 in p16-positivity and High-risk HPV Infection