Central Diabetes Insipidus (cDI)

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Central Diabetes Insipidus (cDI) trials you may qualify for

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 11 trials

RecruitingPhase 2

NCT06036004

Oxytocin Substitution Therapy in Patients With Central Diabetes Insipidus

This randomized, placebo-controlled, double-blind trial aims to investigate intranasal OXT as a novel therapeutical option in central diabetes insipidus (cDI) t…

Germany, Netherlands, Switzerland112 participantsStarted 2024-01-08

Treatment: Intranasal OXT, Placebo nasal spray

RecruitingEarly Phase 1

NCT07568509

Identifying Oxytocin Deficiency in Pediatric Patients With Pituitary Disease

An open-labeled, interventional pilot trial, 10 youth with AVP-D and 10 PD matched for age, sex, and BMI will be recruited from Pediatric Endocrinology and Neur…

United States20 participantsStarted 2026-05

Treatment: Norethindrone Acetate-Ethinyl Estradiol

RecruitingNot Applicable

NCT06742060

The Trend of Copeptin Levels and Its Clinical Value for Postoperative CDI in Pediatric Patients After NSI in ICU

Central diabetes insipidus (CDI),a disease caused by the decrease of AVP (a hormone involved in the control of water-electrolyte balance ) secretion and charace…

China100 participantsStarted 2024-11-22

Treatment: serum copeptin levels

RecruitingNot Applicable

NCT07276152

Plasma Oxytocin Changes in Response to Music Modified by Sonic Augmentation Technology

The investigator aim to investigate wheather music modified by sonic augmentation technology can produce increasing oxytocin levels with minimal to no side effe…

Switzerland22 participantsStarted 2026-01-09

Treatment: sonic augmentation technology

RecruitingNot Applicable

NCT07361263

Plasma Oxytocin Response to Oral Estrogens in Healthy Controls and AVP-Deficiency

The PHOENIX study aims to investigate whether oral estradiol valerate (EV) and ethinylestradiol (EE) can stimulate oxytocin (OXT) and neurophysin-1 (NP-1) relea…

Switzerland28 participantsStarted 2026-01-09

Treatment: estradiol valerate, esthinylestradiol

RecruitingPhase 2

NCT06808516

Effects of Intranasal Oxytocin on Sexual Well-Being in Patients With Arginine Vasopressin Deficiency and Healthy Control…

The study aims to investigate whether intranasal oxytocin (OXT) improves sexual well-being in patients with Arginine Vasopressin Deficiency (AVP-D). The trial c…

Switzerland42 participantsStarted 2025-07-01

Treatment: Oxytocin nasal spray, Placebo

All recent trials (29 shown)

Not Yet RecruitingNot Applicable

NCT07569861

Copeptin Measurement After Mannitol and Hypertonic Saline for the Diagnosis of Polyuria-polydipsia Syndrome

The aim of this study is to evaluate whether a new test using mannitol infusion can diagnose the cause of polyuria-polydipsia syndrome as accurately as the curr…

Switzerland144 participantsStarted 2026-07

Treatment: Mannitol, Hypertonic Saline

CompletedPhase 4

NCT04897802

Identification and Clinical Relevance of an Oxytocin Deficient State (GLP1 Study)

Oxytocin (OT) is a hypothalamic peptide that enters the peripheral circulation via the posterior pituitary gland. OT plays a key role in regulating appetite, ps…

Spain42 participantsStarted 2021-09-13

Treatment: Experimental: GLP1-RA (exenatide) administration, Control: Placebo administration

Central Diabetes Insipidus (cDI)

Trial phase breakdown

Trial status

Actively recruiting — 11 trials

Oxytocin Substitution Therapy in Patients With Central Diabetes Insipidus

Identifying Oxytocin Deficiency in Pediatric Patients With Pituitary Disease

The Trend of Copeptin Levels and Its Clinical Value for Postoperative CDI in Pediatric Patients After NSI in ICU

Plasma Oxytocin Changes in Response to Music Modified by Sonic Augmentation Technology

Plasma Oxytocin Response to Oral Estrogens in Healthy Controls and AVP-Deficiency

Effects of Intranasal Oxytocin on Sexual Well-Being in Patients With Arginine Vasopressin Deficiency and Healthy Control…

All recent trials (29 shown)

Copeptin Measurement After Mannitol and Hypertonic Saline for the Diagnosis of Polyuria-polydipsia Syndrome

Identification and Clinical Relevance of an Oxytocin Deficient State (GLP1 Study)

Trial phase breakdown

Trial status

Actively recruiting — 11 trials

Oxytocin Substitution Therapy in Patients With Central Diabetes Insipidus

Identifying Oxytocin Deficiency in Pediatric Patients With Pituitary Disease

The Trend of Copeptin Levels and Its Clinical Value for Postoperative CDI in Pediatric Patients After NSI in ICU

Plasma Oxytocin Changes in Response to Music Modified by Sonic Augmentation Technology

Plasma Oxytocin Response to Oral Estrogens in Healthy Controls and AVP-Deficiency

Effects of Intranasal Oxytocin on Sexual Well-Being in Patients With Arginine Vasopressin Deficiency and Healthy Control…

All recent trials (29 shown)

Copeptin Measurement After Mannitol and Hypertonic Saline for the Diagnosis of Polyuria-polydipsia Syndrome

Identification and Clinical Relevance of an Oxytocin Deficient State (GLP1 Study)

Mannitol-induced Release of Copeptin in Healthy Adults and Patients With Polyuria-Polydipsia Syndrome (MARS Study)

Arginin-stimulated Copeptin in Polyuria-polydipsia Syndrome in Children

Plasma Copeptin in Response to Oral Urea in Healthy Adults and Patients With Polyuria-polydipsia Syndrome

Identification and Clinical Relevance of an Oxytocin Deficient State (Melatonin Study)

Identification and Clinical Relevance of an Oxytocin Deficient State (CRH Study)

Electrophysiology of the Human Pituitary Gland

Efficacy, Safety, and Tolerability Study of Oral Full-Spectrum MicrobiotaTM (CP101) in Subjects With Recurrent C. Diff

Open-Label Extension of CP101 Trials Evaluating Oral Full-Spectrum Microbiota™ (CP101) in Subjects With Recurrence of Cl…

Fecal Microbiota Transplantation for Early Clostridioides Difficile Infection

Copeptin as a Biomarker for Central Diabetes Insipidus Development Following Pituitary Surgery

Copeptin After a Subcutaneous Stimulation With Glucagon in Adults

Circulating Oxytocin Changes in Response to the Oxytocin System Stimulator MDMA in Patients With Diabetes Insipidus and…

Seoul National University Pituitary Disease Cohort Study

Vasopressin Deficiency in Hemorrhagic Shock

A Study of Minirin Melt in Japanese Patients With Central Diabetes Insipidus (CDI).

Study of the Pathogenesis and Pathophysiology of Familial Neurohypophyseal Diabetes Insipidus