Copeptin After a Subcutaneous Stimulation With Glucagon in Adults

Inclusion Criteria for healthy volunteers: * no medication except hormonal contraception Inclusion criteria for patients: * Documented primary polydipsia or diabetes insipidus based on a water deprivation test or hypertonic saline Infusion * Accordingly patients must have evidence of disordered drinking habits and diuresis defined as polyuria \>50ml/kg body weight/24h and polydipsia \>3l /24h, or must be on regular daily Desmopressin medication. Exclusion Criteria for healthy volunteers: * BMI \> 25kg/m2 or \< 18.5 kg/m2 * participation in a trial with investigational drugs within 30 days * vigorous physical exercise within 24 hours before the study participation * Alcohol intake within 24 hours before study participation * pregnancy and breastfeeding * Evidence of disordered drinking habits and diuresis defined as polyuria \>50ml/kg Body weight/24h and polydipsia \>3l /24h * Intention to become pregnant during the study * Known allergy towards glucagon * Evidence of an acute illness * Long QT syndrome * Hemoglobin level below 120 g/l Exclusion criteria for patients: * BMI \> 25kg/m2 or \< 18.5 kg/m2 * participation in a trial with investigational drugs within 30 days * vigorous physical exercise within 24 hours before the study participation * Alcohol intake within 24 hours before study participation * pregnancy and breastfeeding * Evidence of an acute illness * Long QT syndrome * Hemoglobin level below 120 g/l