APDS

Clinical trial pipeline · Data from ClinicalTrials.gov

See which APDS trials you may qualify for

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 3 trials

RecruitingNot Applicable

NCT06694363

New Biomarker-based Strategy to Screen and Monitor for Activated Phosphoinositide 3-kinase δ Syndrome

The study would like to compare patient samples at different time points using state-of the art-phenotyping tools. Collection of blood samples of APDS patients…

France14 participantsStarted 2025-06-26

Treatment: Blood samples, Urine samples

RecruitingNot Applicable

NCT03891251

Collecting Recorded Videos of Colonoscopy

The study shall mainly help to better evaluate the performance the APDS device and secondly it may help to assess the potential of the future alpha version of t…

Israel700 participantsStarted 2018-12-19

Treatment: Collecting recorded videos of Colonoscopy screening tests

RecruitingNot Applicable

NCT06566872

Collecting Recorded Videos of Colonoscopy and Gastroscopy Tests for the Evaluation of the (ME-APDS).

The study shall mainly help to better evaluate the performance the ME-APDS device and secondly it may help the development of additional future versions of the…

Israel700 participantsStarted 2022-05-16

Treatment: ME-APDS

All recent trials (58 shown)

Active — Not RecruitingPhase 3

NCT05438407

Pediatric Patients Aged 4 to 11 Years With APDS

This is a 2-part, prospective, open-label, single arm, multicenter study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PDx), an…

United States, France15 participantsStarted 2023-02-01

Treatment: Leniolisib

TerminatedPhase 2/3

NCT02859727

Extension to the Study of Efficacy of CDZ173 in Patients With APDS/PASLI

This study is designed to provide long-term CDZ173 treatment, a selective PI3Kδ inhibitor, to the patients with genetically activated PI3Kδ, i.e., patients with…

United States, Belarus +3 more37 participantsStarted 2016-09-08

Treatment: CDZ173

APDS

Trial phase breakdown

Trial status

Actively recruiting — 3 trials

New Biomarker-based Strategy to Screen and Monitor for Activated Phosphoinositide 3-kinase δ Syndrome

Collecting Recorded Videos of Colonoscopy

Collecting Recorded Videos of Colonoscopy and Gastroscopy Tests for the Evaluation of the (ME-APDS).

All recent trials (58 shown)

Pediatric Patients Aged 4 to 11 Years With APDS

Extension to the Study of Efficacy of CDZ173 in Patients With APDS/PASLI

Trial phase breakdown

Trial status

Actively recruiting — 3 trials

New Biomarker-based Strategy to Screen and Monitor for Activated Phosphoinositide 3-kinase δ Syndrome

Collecting Recorded Videos of Colonoscopy

Collecting Recorded Videos of Colonoscopy and Gastroscopy Tests for the Evaluation of the (ME-APDS).

All recent trials (58 shown)

Pediatric Patients Aged 4 to 11 Years With APDS

Extension to the Study of Efficacy of CDZ173 in Patients With APDS/PASLI

PI3K Delta Inhibitor in Relapsed / Refractory Autoimmune Hemolytic Anemia Patients After Receiving Two or More Lines of…

Pediatric Patients Aged 1 to 6 Years With APDS

A Phase I/Ib Safety and Efficacy Study of the PI3K-delta Inhibitor TGR-1202 and Ibrutinib in Patients With CLL or MCL

Efficacy and Safety of Tenalisib (RP6530) in Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL)

Rapamycin Treatment for Activated Phosphoinositide 3-Kinase δ Syndrome

Evaluate the Efficacy and Safety of TGR-1202 in Participants With Chronic Lymphocytic Leukemia Who Are Intolerant to Pri…

Effect of Local Pamidronate in Preventing Bone Loss After Total Hip Arthroplasty

CVL237 Tablets for APDS/PASLI

Prevention of Bone Loss After Pediatric Hematopoietic Cell Transplantation

An Open-Label Study to Assess the Safety & Efficacy of Leniolisib in Japanese Patients With APDS

Prevention of Post Operative Bone Loss in Children

Pamidronate Administration in Breast Cancer Patients With Bone Metastases

Biomarker Identification in Orthopaedic & Oral Maxillofacial Surgery Subjects to Identify Risks of Bisphosphonate Use

Study of Efficacy of CDZ173 in Patients With APDS/PASLI

A Study to Evaluate the Safety and Efficacy of the Use of ME-APDS During Colonoscopy

Safety, Pharmacokinetic (PK) and Pharmacodynamic (PD) Study of Repeat Doses of Inhaled Nemiralisib in Patients With APDS…

Collecting Recorded Videos of Colonoscopy Tests

Safety and Efficacy Study of a Dual PI3K Delta/Gamma Inhibitor in T-cell Lymphoma