TerminatedPhase 2/3

Extension to the Study of Efficacy of CDZ173 in Patients With APDS/PASLI

Stopped: All participant have transitioned to commercial product or compassionate use.

United States, Belarus, Czechia37 participantsStarted 2016-09-08

Plain-language summary

This study is designed to provide long-term CDZ173 treatment, a selective PI3Kδ inhibitor, to the patients with genetically activated PI3Kδ, i.e., patients with APDS/PASLI who participated in the CCDZ173X2201 study or who were treated previously with PI3Kδ inhibitors other than CDZ173. The study is open-label designed to establish the long-term safety, tolerability, efficay and pharmacokinetics of CDZ173 in the target population.

Who can participate

Age range12 Years – 75 Years

SexALL

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Inclusion Criteria: * Written informed consent must be obtained before any assessment is performed. * Paients must have participated in the study CCDZ173X2201 or were treated previously with PI3Kδ inhibitors other than CDZ173. * Patients who are deemed by the Investigator to benefit from PI3Kδ inhibitor therapy. * Patients or their legal representatives (for patients under the age of 18 years) must be able to communicate well with the Investigator, to understand and comply with the requirements of the study. * Documented APDS/PASLI-associated genetic PI3K delta mutation. Exclusion Criteria: \- Any medically significant disease or condition that is unrelated to APDS/PASLI Other protocol-defined inclusion/exclusion criteria may apply.

What they're measuring

To Evaluate the Number of Participants With (S)AEs During Treatment With CDZ173

Timeframe: 6 years 3 months

Trial details

NCT IDNCT02859727

SponsorPharming Technologies B.V.

Sponsor typeINDUSTRY

Study typeINTERVENTIONAL

Primary completion2025-01-30

Results submitted2025-12-11