Advanced Leiomyosarcoma

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Advanced Leiomyosarcoma trials you may qualify for

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 14 trials

RecruitingPhase 1/2

NCT06975293

STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers and as Monotherapy in Participants…

This early phase oncology trial will be conducted at various study centers to investigate the safety, tolerability, and antitumor activity of STC-15 (a METTL3 i…

United States107 participantsStarted 2025-05-05

Treatment: STC-15 in combination with toripalimab, STC-15 monotherapy

RecruitingPhase 2

NCT06638931

Agnostic Therapy in Rare Solid Tumors

The ANTARES study is a phase II basket trial designed to evaluate the tissue-agnostic efficacy of the monoclonal anti-PD1 antibody, nivolumab, in patients with…

Brazil28 participantsStarted 2024-07-16

Treatment: Nivolumab

RecruitingPhase 1

NCT05711615

Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Adv…

This phase I trial tests the safety, side effects, and best dose of combination therapy with liposomal doxorubicin and peposertib in treating patients with sarc…

United States30 participantsStarted 2024-02-06

Treatment: Biopsy Procedure, Biospecimen Collection

RecruitingPhase 1/2

NCT06498648

Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tis…

This phase I/II trial tests the side effects and best dose of abemaciclib when added to gemcitabine and compares the effectiveness of that treatment to the usua…

United States74 participantsStarted 2026-03-18

Treatment: Abemaciclib, Biopsy Procedure

RecruitingPhase 2

NCT07516925

A Study of Ivonescimab in People With Leiomyosarcoma

The purpose of this study is to find out if Ivonescimab is an effective and safe treatment that causes few or mild side effects for people with advanced/unresec…

United States20 participantsStarted 2026-04-01

Treatment: Ivonescimab

RecruitingPhase 2

NCT04383119

Trial in Patients With Metastatic or Locally Advanced Leiomyosarcoma

Study is aimed at evaluating the activity of Trabectedin (arm A) in advanced leiomyosarcomas, having Gemcitabine (arm B) as the comparator. In addition to the…

Italy100 participantsStarted 2021-10-29

Treatment: Trabectedin, Gemcitabine

All recent trials (99 shown)

CompletedPhase 2

NCT04807816

Targeting ATR in Soft-tissue Sarcomas

Multicenter, prospective, open-labeled, 2-arm, non-comparative randomized phase II trial to assess the antitumor activity of berzosertib in association with gem…

France58 participantsStarted 2022-02-09

Treatment: Association of berzosertib with gemcitabine, Gemcitabine

Active — Not RecruitingPhase 2

NCT05836571

Testing Ipilimumab and Nivolumab Combination With or Without Cabozantinib in People >= 18 Years Old With Advanced Soft T…

This phase II trial compares the effect of immunotherapy with ipilimumab and nivolumab alone to their combination with cabozantinib in treating patients with so…

United States66 participantsStarted 2023-10-25

Treatment: Biopsy Procedure, Biospecimen Collection

Advanced Leiomyosarcoma

Trial phase breakdown

Trial status

Actively recruiting — 14 trials

STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers and as Monotherapy in Participants…

Agnostic Therapy in Rare Solid Tumors

Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Adv…

Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tis…

A Study of Ivonescimab in People With Leiomyosarcoma

Trial in Patients With Metastatic or Locally Advanced Leiomyosarcoma

All recent trials (99 shown)

Targeting ATR in Soft-tissue Sarcomas

Testing Ipilimumab and Nivolumab Combination With or Without Cabozantinib in People >= 18 Years Old With Advanced Soft T…

Trial phase breakdown

Trial status

Actively recruiting — 14 trials

STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers and as Monotherapy in Participants…

Agnostic Therapy in Rare Solid Tumors

Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Adv…

Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tis…

A Study of Ivonescimab in People With Leiomyosarcoma

Trial in Patients With Metastatic or Locally Advanced Leiomyosarcoma

All recent trials (99 shown)

Targeting ATR in Soft-tissue Sarcomas

Testing Ipilimumab and Nivolumab Combination With or Without Cabozantinib in People >= 18 Years Old With Advanced Soft T…

Lurbinectedin + Doxorubicin In Leiomyosarcoma

Testing Olaparib and Temozolomide Versus the Usual Treatment for Uterine Leiomyosarcoma After Chemotherapy Has Stopped W…

A Trial for Advanced Leiomyosarcoma With Human Organoid-guided Personalized Efficacy

Study of DNA Damage, Angiogenesis, and PD-L1 Inhibitors in Advanced Solid Tumors

Study of the CHK1 Inhibitor BBI-355, an ecDNA-directed Therapy (ecDTx), and the RNR Inhibitor BBI-825, in Subjects With…

Combination of MK3475 and Metronomic Cyclophosphamide in Patients With Advanced Sarcomas : Multicentre Phase II Trial

Lenvatinib and Eribulin in Advanced Soft Tissue Sarcoma

A Phase II Clinical Trial Evaluating the Combination of Olaparib and Temozolomide for the Treatment of Advanced Uterine…

Study of DCC-3014 in Combination With Avelumab in Patients With Advanced or Metastatic Sarcomas

NM32-2668 in Adult Patients With Selected Advanced Solid Tumors

A Study of Doxorubicin Plus Olaratumab (LY3012207) in Participants With Advanced or Metastatic Soft Tissue Sarcoma

A Study of Unesbulin in Participants With Advanced Leiomyosarcoma (LMS)

Multi-Arm Study to Test the Efficacy of Immunotherapeutic Agents in Multiple Sarcoma Subtypes

APX005M and Doxorubicin in Advanced Sarcoma

Phase II Trial of Ribociclib and Everolimus in Advanced Dedifferentiated Liposarcoma (DDL) and Leiomyosarcoma (LMS)

Nanatinostat Plus Valganciclovir in Advanced EBV+ Solid Tumors and in Combination With Pembrolizumab in EBV+ RM-NPC

Nivolumab Alone or in Combination With Ipilimumab in Treating Patients With Advanced Uterine Leiomyosarcoma

Trial of Sunitinib and/or Nivolumab Plus Chemotherapy in Advanced Soft Tissue and Bone Sarcomas