Acid Base Imbalance

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Acid Base Imbalance trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 33 trials

RecruitingPhase 2

NCT04984226

Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD

Skeletal muscle metabolic health is critical for mobility and an underrecognized target of metabolic acidosis in chronic kidney disease. Impaired muscle mitocho…

United States80 participantsStarted 2023-09-08

Treatment: Sodium bicarbonate, placebo

RecruitingPhase 3

NCT07355062

A Study to Evaluate the Efficacy and Safety of Veverimer for the Treatment of Metabolic Acidosis

The purpose of this 26 week study is is to evaluate the efficacy and safety of veverimer in treating adults with moderate-to-severe chronic kidney disease (CKD)…

United States150 participantsStarted 2026-01-13

Treatment: Veverimer, Placebo

RecruitingPhase 4

NCT07527156

Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure

This study will evaluate the feasibility and safety of achieving therapeutic concentrations of beta-hydroxybutyrate using continuous infusion of D-beta-hydroxyb…

Czechia12 participantsStarted 2026-04-04

Treatment: Ketone Monoester (KE)

RecruitingEarly Phase 1

NCT05057806

SGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research Plan

The study team will examine the effects of SGLT2i (and SGLT2i-induced increases in plasma ketone concentrations) on skeletal muscle and cardiac ketone uptake, s…

United States30 participantsStarted 2021-01-13

Treatment: Empagliflozin 25 MG, Placebo

RecruitingNot Applicable

NCT06078683

Effects of Ketone Ester Consumption on Exercise Tolerance and Cardiac Function

This study is being done to evaluate how a ketone ester (KE) supplement affects heart function and health in people with diabetes compared to a placebo suppleme…

United States30 participantsStarted 2023-06-06

Treatment: Ketone Ester Acute, Placebo Acute

RecruitingNot Applicable

NCT06236607

Hybrid Closed Loop Effectiveness Trial in Adults With Type 1 Diabetes

Minoritized individuals with type 1 diabetes (T1D) have approximately 2% higher average A1c levels and twice the rate of hospitalizations, complications, and mo…

United States140 participantsStarted 2025-02-27

Treatment: Device specific training, Study clinician/educator visit

All recent trials (100 shown)

Not Yet RecruitingNot Applicable

NCT07576374

Specificities of Atypical Non AutoImmune Diabetes (ANAID) in the French West Indies

Genetics variants could be involved in atypical non-autoimmune diabetes revealed by ketoacidosis. The objective of this research will be to determine the relati…

Guadeloupe118 participantsStarted 2026-06

Not Yet RecruitingPhase 2/3

NCT06807918

Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder

This is a randomized, double-blind, crossover trial to evaluate the immediate effects of a nutritional ketone supplement, Kenotic compared to placebo on brain f…

United States60 participantsStarted 2026-06

Treatment: Kenetik, magnetic resonance imaging scan

Acid Base Imbalance

Trial phase breakdown

Trial status

Actively recruiting — 33 trials

Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD

A Study to Evaluate the Efficacy and Safety of Veverimer for the Treatment of Metabolic Acidosis

Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure

SGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research Plan

Effects of Ketone Ester Consumption on Exercise Tolerance and Cardiac Function

Hybrid Closed Loop Effectiveness Trial in Adults With Type 1 Diabetes

All recent trials (100 shown)

Specificities of Atypical Non AutoImmune Diabetes (ANAID) in the French West Indies

Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder

Trial phase breakdown

Trial status

Actively recruiting — 33 trials

Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD

A Study to Evaluate the Efficacy and Safety of Veverimer for the Treatment of Metabolic Acidosis

Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure

SGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research Plan

Effects of Ketone Ester Consumption on Exercise Tolerance and Cardiac Function

Hybrid Closed Loop Effectiveness Trial in Adults With Type 1 Diabetes

All recent trials (100 shown)

Specificities of Atypical Non AutoImmune Diabetes (ANAID) in the French West Indies

Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder

Ketones in Heart Failure With Reduced Ejection Fraction

Sodium Bicarbonate for Critically Ill Patients With Metabolic Acidosis and Acute Kidney Injury

An Open-label Extension Safety Study of MELAS Patients Who Completed TIS6463-203 (PRIZM)

Exogenous Ketones and Appetite

Assessment of BHB Concentration Agreement Among Sampling Locations and the Impact of Ketosis on EPO, and More

A Study of Tris-Hydroxymethyl Aminomethane (THAM) Versus Sodium Bicarbonate in Cardiac Surgical Patients

A Medium Chain Triglyceride Intervention for Patients With Alzheimer Disease

Efficacy of Volume Ventilation in Patients With Acute Respiratory Failure at Risk of Obstructive Apneas or Obesity Hypov…

High Flow Oxygen in Patients Undergoing Suspension Laryngoscopy Under General Anesthesia

Modeling Ketosis-Prone Diabetes Remission Via Diverse Mechanisms of Glucotoxicity

Effect of Nutritional Ketosis on Alcohol Metabolism

Effects of Ketone Supplementation on Acute Alcohol Withdrawal

Reducing Dietary Acid With Food Versus Oral Alkali in People With Chronic Kidney Disease (ReDACKD)

Exogenous Ketone Supplementation in ICU Delirium

Therapeutic Education in Very Young Children With Diabetes Mellitus

Low-CArbohydrate Diet and SGLT2-INhibitOr to Achieve Moderate Ketosis in Healthy Volunteers

SODium BICarbonate for Metabolic Acidosis in the ICU

A Phase 2b Study of Zagociguat in Patients With MELAS