Not Yet RecruitingPhase 4

A Study of Tris-Hydroxymethyl Aminomethane (THAM) Versus Sodium Bicarbonate in Cardiac Surgical Patients

United States250 participantsStarted 2026-05

Plain-language summary

The purpose of this research is to determine if two commonly used medications to treat metabolic acidosis in the setting of cardiac surgery, sodium bicarbonate and THAM, are equivalent.

Who can participate

Age range21 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

* Inclusion criteria * Cardiothoracic surgery with use of cardiopulmonary bypass * Presence of metabolic acidosis (defined as a base excess of \<-5) * Minnesota Research Authorization * Exclusion criteria * Non-cardiac surgery patients or cardiac surgery without cardiopulmonary bypass * Absence of metabolic acidosis (metabolic acidosis being defined as a base excess of \<-5) * Pregnant patients * Prisoners * Opt out of Minnesota Research Authorization

What they're measuring

Change in pH following buffer administration

Timeframe: Baseline, 2 hours

Trial details

NCT IDNCT07424625

SponsorMayo Clinic

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-02

Contact for this trial

Nicole M. Lenort, RRT, LRT

866-265-9263 Lenort.Nicole@mayo.edu

View on ClinicalTrials.gov More Metabolic Acidosis trials