Acid Base Disorder

Clinical trial pipeline · Data from ClinicalTrials.gov

See which Acid Base Disorder trials you may qualify for

100

Total trials

Actively recruiting

Phase 3 trials

Completed

Trial phase breakdown

Trial status

Actively recruiting — 39 trials

RecruitingPhase 2

NCT04984226

Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD

Skeletal muscle metabolic health is critical for mobility and an underrecognized target of metabolic acidosis in chronic kidney disease. Impaired muscle mitocho…

United States80 participantsStarted 2023-09-08

Treatment: Sodium bicarbonate, placebo

RecruitingPhase 3

NCT07355062

A Study to Evaluate the Efficacy and Safety of Veverimer for the Treatment of Metabolic Acidosis

The purpose of this 26 week study is is to evaluate the efficacy and safety of veverimer in treating adults with moderate-to-severe chronic kidney disease (CKD)…

United States150 participantsStarted 2026-01-13

Treatment: Veverimer, Placebo

RecruitingNot Applicable

NCT00001456

Clinical and Basic Investigations Into Hermansky-Pudlak Syndrome

Hermansky-Pudlak Syndrome (HPS) is an inherited disease which results in decreased pigmentation (oculocutaneous albinism), bleeding problems due to a platelet a…

United States600 participantsStarted 1995-11-06

RecruitingNot Applicable

NCT07522684

Polynucleotide + Hyaluronic Acid Gel With Xenogeneic Graft for Intrabony Periodontal Defects

Over the last 30 years, the prevalence of periodontitis (PE) has increased substantially, including among younger populations, highlighting the need to improve…

Brazil66 participantsStarted 2026-02-25

Treatment: Polynucleotide and hyaluronic acid-based gel, Control

RecruitingPhase 1/2

NCT04998396

A Study of AAV9 Gene Therapy in Participants With Canavan Disease (CANaspire Clinical Trial)

The main objective of this trial is to evaluate the safety, tolerability, and pharmacodynamic activity of BBP-812, an investigational AAV9-based gene therapy, i…

United States26 participantsStarted 2021-09-08

Treatment: AAV9 BBP-812

RecruitingPhase 4

NCT07527156

Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure

This study will evaluate the feasibility and safety of achieving therapeutic concentrations of beta-hydroxybutyrate using continuous infusion of D-beta-hydroxyb…

Czechia12 participantsStarted 2026-04-04

Treatment: Ketone Monoester (KE)

All recent trials (100 shown)

Not Yet RecruitingNot Applicable

NCT07576374

Specificities of Atypical Non AutoImmune Diabetes (ANAID) in the French West Indies

Genetics variants could be involved in atypical non-autoimmune diabetes revealed by ketoacidosis. The objective of this research will be to determine the relati…

Guadeloupe118 participantsStarted 2026-06

CompletedNot Applicable

NCT07033312

Therapeutic Effect of Oral Hyaluronic Acid on Knee Osteoarthritis

The goal of this clinical trial is to investigate the effect of oral hyaluronate in patients with knee osteoarthritis. The main question it aims to answer is: t…

Taiwan44 participantsStarted 2023-04-21

Treatment: oral hyaluronate and injection, hyaluronate injection

Acid Base Disorder

Trial phase breakdown

Trial status

Actively recruiting — 39 trials

Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD

A Study to Evaluate the Efficacy and Safety of Veverimer for the Treatment of Metabolic Acidosis

Clinical and Basic Investigations Into Hermansky-Pudlak Syndrome

Polynucleotide + Hyaluronic Acid Gel With Xenogeneic Graft for Intrabony Periodontal Defects

A Study of AAV9 Gene Therapy in Participants With Canavan Disease (CANaspire Clinical Trial)

Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure

All recent trials (100 shown)

Specificities of Atypical Non AutoImmune Diabetes (ANAID) in the French West Indies

Therapeutic Effect of Oral Hyaluronic Acid on Knee Osteoarthritis

Trial phase breakdown

Trial status

Actively recruiting — 39 trials

Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD

A Study to Evaluate the Efficacy and Safety of Veverimer for the Treatment of Metabolic Acidosis

Clinical and Basic Investigations Into Hermansky-Pudlak Syndrome

Polynucleotide + Hyaluronic Acid Gel With Xenogeneic Graft for Intrabony Periodontal Defects

A Study of AAV9 Gene Therapy in Participants With Canavan Disease (CANaspire Clinical Trial)

Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure

All recent trials (100 shown)

Specificities of Atypical Non AutoImmune Diabetes (ANAID) in the French West Indies

Therapeutic Effect of Oral Hyaluronic Acid on Knee Osteoarthritis

Individualized Treatment Treating Patients With Stage II-IVB Nasopharyngeal Cancer Based on EBV DNA

Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder

Ketones in Heart Failure With Reduced Ejection Fraction

Sodium Bicarbonate for Critically Ill Patients With Metabolic Acidosis and Acute Kidney Injury

An Open-label Extension Safety Study of MELAS Patients Who Completed TIS6463-203 (PRIZM)

Exogenous Ketones and Appetite

Assessment of BHB Concentration Agreement Among Sampling Locations and the Impact of Ketosis on EPO, and More

A Study of Tris-Hydroxymethyl Aminomethane (THAM) Versus Sodium Bicarbonate in Cardiac Surgical Patients

A Medium Chain Triglyceride Intervention for Patients With Alzheimer Disease

Glyceryl Eicosapentaenoate Based Topic Products as an Irritant-free Cream and Serum for Hydration of Sensitive Skin

Efficacy of Volume Ventilation in Patients With Acute Respiratory Failure at Risk of Obstructive Apneas or Obesity Hypov…

Evaluation of PKU Sphere in Italy

High Flow Oxygen in Patients Undergoing Suspension Laryngoscopy Under General Anesthesia

Modeling Ketosis-Prone Diabetes Remission Via Diverse Mechanisms of Glucotoxicity

Effect of Nutritional Ketosis on Alcohol Metabolism

Effects of Ketone Supplementation on Acute Alcohol Withdrawal

Reducing Dietary Acid With Food Versus Oral Alkali in People With Chronic Kidney Disease (ReDACKD)

Exogenous Ketone Supplementation in ICU Delirium