Magnesium Oxide and Letrozole Versus Letrozole Alone on Ovarian Response in Insulin Resistant PCOS (NCT07766590) | Clinical Trial Compass
CompletedNot Applicable
Magnesium Oxide and Letrozole Versus Letrozole Alone on Ovarian Response in Insulin Resistant PCOS
Bangladesh60 participantsStarted 2025-06-01
Plain-language summary
Does pretreatment with magnesium oxide followed by letrozole increase ovulation rate? What medical problems do participants have when taking drug magnesium oxide and letrozole? Researchers will compare magnesium oxide and letrozole to letrozole alone to see pretreatment with magnesium oxide followed by letrozole works better as ovulation induction.
Experimental group will receive magnesium oxide and letrozole alone. Comparator group will receive letrozole alone.
Who can participate
Age range
18 Years – 35 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* All PCOS patients who fulfill the Rotterdam diagnostic criteria
* Primary or secondary subfertility
* Women of age: 18-35yr
* Insulin resistance (HOMA-IR\>2) (Hydrie et al.,2012)
Exclusion Criteria:
* Male factor
* Uterine, tubal and endometrial factor
* Pelvic inflammatory disease
* Patient with other endocrine disease like hypothyroidism, hyperthyroidism, congenital adrenal hyperplasia, Diabetes mellitus and hyperprolactinemia.
* BMI less than 18.5 or more than 30.
* Known allergy to magnesium oxide
* Any medication in the last 3 months which would affect insulin resistance (metformin, myoinositol)
* Conditions with a high risk for hypomagnesemia such as using diuretics, alcoholism, persistent diarrhoea.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Ovulation rate
Timeframe: Assessed on 21st day of menstruation
2
Proportion of patients developing mature follicle
Timeframe: Day 12 to day 14 of menstruation
3
Proportion of patients developing endometrial thickness more than 7mm