Comparative Effects of CIMT and TOT on Hand Function in Post Stroke Patients (NCT07764939) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Comparative Effects of CIMT and TOT on Hand Function in Post Stroke Patients
Pakistan48 participantsStarted 2025-07-12
Plain-language summary
This controlled clinical study investigates and compares the effectiveness of CIMT and TOT in improving hand function among post-stroke patients. A total of 48 participants from hospitals in Sialkot will be randomly divided into two groups and receive a 3-week intervention consisting of 15 sessions. Outcomes will be assessed using the 9-Hole Peg Test, Jebsen-Taylor Hand Function Test, and grip strength, and the data will be analyzed using SPSS-21 under a single-blinded design.
Who can participate
Age range
45 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria: Participants will be included if they meet the following criteria:
* Age between 45 and 65 years
* Both male and female participants
* First-ever unilateral ischemic or hemorrhagic stroke confirmed by imaging
* Stroke onset in subacute to chronic phase (\>3 months post-stroke)
* Medically stable and able to sit independently
* Voluntary wrist extension of at least 10 degrees and finger extension of at least 10 degrees in the affected hand
* Mini-Mental State Examination (MMSE) score \> 26
* No significant pain or spasticity in affected upper limb (Modified Ashworth Scale \< 2)
* Adequate sitting balance and trunk control for upper limb activities
* Willingness and availability to complete the full intervention (3 weeks)
* No significant musculoskeletal impairments (e.g., fractures or arthritis) affecting the upper limb
Exclusion Criteria: Participants will be excluded if they have:
* Severe spasticity (Modified Ashworth Scale \> 3) or joint contractures
* Severe aphasia, neglect, or cognitive impairments affecting task performance
* Recurrent or bilateral stroke
* Severe upper limb impairment
* Joint contractures or orthopedic limitations in the upper limb
* Active infections, skin lesions, or wounds on the upper limb
* Severe pain during limb movement
* Participation in other upper limb rehabilitation programs concurrently
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.