Pinhole Regenerative Therapy (PRT) following minimally invasive non-surgical periodontal therapy (MINST) in the treatment of intrabony defects associated with Stage III Grade B periodontitis. Eligible patients with 2- or 3-wall intrabony defects will be randomly allocated to the study groups. Clinical outcomes, including probing pocket depth (PPD) reduction and clinical attachment level (CAL) gain, together with radiographic bone defect fill assessed by periapical radiographs and CBCT, will be evaluated over a 6-month follow-up period to determine the effectiveness of the proposed minimally invasive regenerative approacا
Who can participate
Age range
39 Years – 61 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria
* Patients aged 39-61 years.
* Systemically healthy patients.
* Diagnosed with Stage III periodontitis.
* Presence of probing pocket depth (PPD) ≥ 6 mm.
* Presence of clinical attachment loss (CAL) ≥ 4 mm.
* Presence of at least one 2- or 3-wall interproximal intrabony defect with:
* Defect depth ≥ 3 mm.
* Angulation width ≥ 45°.
* Each participant contributed one maxillary or mandibular single- or multi-rooted interproximal intrabony defect.
Exclusion Criteria
* Patients with any systemic condition contraindicating surgical intervention.
* Pregnant or lactating females.
* Smokers.
* Alcoholic patients.
* History of periodontal therapy within the previous 6 months.
* History of antibiotic administration within the previous 6 months.
* Patients with unacceptable oral hygiene after re-evaluation following Step 1 and Step 2 periodontal therapy.
* Teeth with any degree of mobility.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.