The goal of this observational study is to learn more about pancreatic cancer risk in people with chronic pancreatitis. Researchers will study blood markers and gut microorganisms, which are bacteria and other microbes living in the intestine. Researchers will compare healthy participants, participants with chronic pancreatitis, and participants with newly diagnosed pancreatic cancer. The study will examine whether blood markers and gut microorganisms differ among these groups. It will also study how these features change over time and whether they may help identify people with chronic pancreatitis who are at higher risk of pancreatic cancer. Participants will provide blood and stool samples. Researchers will also collect health information, laboratory test results, and abdominal scan results. Participants with chronic pancreatitis will be followed about every 6 to 12 months. Participants with pancreatic cancer will also be followed according to their routine medical care schedule. Researchers will collect information about their treatment, disease changes, test results, scans, and survival status. Some participants with chronic pancreatitis or pancreatic cancer may be asked to provide additional blood or stool samples. Their permission will be confirmed before each additional sample is collected. Refusing an additional sample will not affect their routine medical care or continued follow-up in the study. No treatment will be assigned as part of this study. The findings may help improve future methods for assessing pancreatic cancer risk in people with chronic pancreatitis.
Age range
18 Years
Sex
ALL
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The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Serum or Plasma CXCL10 (IP-10) Concentration
Timeframe: Baseline and approximately every 6 to 12 months thereafter, up to 30 months after enrollment
Serum or Plasma GLYR1 Concentration
Timeframe: Baseline and approximately every 6 to 12 months thereafter, up to 30 months after enrollment
Serum or Plasma TGF-beta Concentration
Timeframe: Baseline and approximately every 6 to 12 months thereafter, up to 30 months after enrollment
Serum or Plasma Artemin Concentration
Timeframe: Baseline and approximately every 6 to 12 months thereafter, up to 30 months after enrollment
Gut Microbiota Shannon Diversity Index
Timeframe: Baseline and approximately every 6 to 12 months thereafter, up to 30 months after enrollment
Gut Microbiota Simpson Diversity Index
Timeframe: Baseline and approximately every 6 to 12 months thereafter, up to 30 months after enrollment