Fatigue in Long-Haul Operations (NCT07761611) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Fatigue in Long-Haul Operations
United States118 participantsStarted 2026-09
Plain-language summary
The purpose of the present study is to test novel countermeasures to reduce fatigue among airline pilots during long-haul flight operations. The investigators will collect objective and subjective sleep, sleepiness, workload, and performance data from active-duty line pilots flying long-haul flight operations (\>8 hours). Data will be collected during days off prior to the trip start, during flights and layover, and during days off following the trip end.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* All medically qualified, active-duty pilots currently flying overnight long-haul operations are eligible to be included as participants in the study. Participants must be line pilots that spend at least 50% of their typical monthly schedule flying long-haul operations (defined at flights over eight hours induration).
Exclusion Criteria:
* Pilots with metabolic disorders, such as diabetes, those actively trying to lose weight or receiving GLP-1 injections, or those who indicate that they are sensitive to light will be excluded from participation. The medical monitor will review the pilot's self-reported medical conditions and medications (if applicable) prior to enrolment in the study.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Vigilant Attention
Timeframe: minimum of 18 days, morning, afternoon, evening and top of descent of all flights
2
Subjective Sleepiness
Timeframe: Minimum of 18 days, morning, afternoon, evening and top of descent of all flights
3
Subjective Fatigue
Timeframe: minimum of 18 days, morning, afternoon, evening and top of descent of all flights
4
Objective Sleep
Timeframe: 24 hours a day for a minimum of 18 days
Trial details
NCT IDNCT07761611
SponsorNational Aeronautics and Space Administration (NASA)