Oxidative Stress and Cardiovascular Risk in Patients With Rheumatoid Arthritis

Inclusion Criteria: * Men or women who are not pregnant or breastfeeding. * Age 18 years or older and younger than 70 years. * Treatment with any disease-modifying antirheumatic drug, including biologic therapies. * For patients receiving oral corticosteroids, a prednisone dose of 10 mg or less that has remained stable for at least one month before study inclusion. * Ability and willingness to provide written informed consent. Exclusion Criteria: * Autoimmune rheumatic disease other than RA, including systemic lupus erythematosus, mixed connective tissue disease, systemic sclerosis, or polymyositis. Sjögren syndrome associated with RA will not be an exclusion criterion. * Functional class IV RA with complete or substantial disability, including confinement to bed or wheelchair that prevents personal self-care. * History or current presence of inflammatory joint disease other than RA, such as gout, reactive arthritis, psoriatic arthritis, seronegative spondyloarthropathy, or Lyme disease. * Estimated glomerular filtration rate below 60 mL/min/1.73 m² or active renal disease. * Pregnancy or breastfeeding. * Evidence of severe uncontrolled concomitant cardiovascular, neurological, pulmonary (including obstructive lung disease), renal, hepatic, endocrine (including diabetes mellitus), or gastrointestinal disease, or any condition considered by the investigator likely to alter the lipid profile. * Body weight greater than 150 kg. * History of alcoholism, drug abuse, or substanc…