Oliceridine-Propofol Dose for Gastroscope Insertion in Obese Patients

Inclusion Criteria: * 18-65 years old, regardless of sex * BMI≥28 kg/m2 * The American Society of Anesthesiologists (ASA) has a rating of II-III * Plan to undergo elective painless digestive endoscopy * The subjects understand the purpose and steps of this experiment, voluntarily participate in this experiment, and sign a written informed consent Exclusion Criteria: * Known to be allergic to drugs used in the examination process * Diagnosed respiratory diseases (asthma, bronchitis, chronic obstructive pulmonary disease, pulmonary embolism, pulmonary edema, lung cancer or upper respiratory tract infection) * Cardiovascular diseases (heart failure, unstable angina pectoris, myocardial infarction or arrhythmia) have been diagnosed * Current hepatic insufficiency (Child-Pugh grade B or above) or renal insufficiency (estimated glomerular filtration rate \< 60 ml/min/1.73 m2) * History of difficult airway (Mallampati Grade IV or expected difficult airway) * Long-term use of opioids (regular use of opioids for more than 7 days within 3 months before operation) * Pregnant or lactating women * Mental illness or cognitive dysfunction can not cooperate