Gentle Skin Abrasion and EMG-Based Neuromuscular Blockade Monitoring
United States55 participantsStarted 2023-10-03
Plain-language summary
This study will evaluate whether gentle skin abrasion improves electromyographic signal quality during neuromuscular blockade monitoring in adult surgical patients.
Participants will receive standard TwitchView electromyographic neuromuscular blockade monitoring on one wrist and TwitchView monitoring after gentle skin abrasion on the opposite wrist. The study will compare electromyographic response amplitudes and supramaximal stimulus currents between routine electrode application and electrode application after skin preparation.
The study procedures will occur during scheduled surgery and will not alter the anesthetic or surgical management of participants.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult surgical patient aged 18 years or older
* Classified as American Society of Anesthesiologists Physical Status I, II, or III
* Scheduled to undergo an elective procedure in which use of a neuromuscular blocking drug is anticipated
* Neuromuscular blockade monitoring would be standard care for the planned procedure
* Procedure allows access to both wrists
* Capable of signing informed consent
Exclusion Criteria:
* Emergency procedure
* Procedure in which neuromuscular blocking drugs are not anticipated
* Access to at least one wrist and ankle is not possible
* Unable to provide informed consent
* Prior stroke
* Hemiparesis or hemiplegia
* Any other known neuromuscular disorder
* Employee or student of the researcher
* Pregnant women, fetuses, neonates, prisoners, children, or adults unable to consent
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
EMG Response Amplitude Before Neuromuscular Blocking Drug Administration
Timeframe: During surgery, before paralytic drug administration