The First-Night Effect and Sex Differences in Strength and Muscular Endurance Performance (NCT07758166) | Clinical Trial Compass
CompletedNot Applicable
The First-Night Effect and Sex Differences in Strength and Muscular Endurance Performance
Spain32 participantsStarted 2024-02-07
Plain-language summary
Introduction: The first-night effect, characterized by disturbed sleep in an unfamiliar environment, may impair next-day physical performance. However, whether this response differs between men and women remains unclear. This study investigated sex differences in the effects of sleeping in an unfamiliar environment on strength and muscular endurance in resistance-trained individuals.
Methods: Thirty-two resistance-trained participants (16 women, 16 men; 23 ± 4 years) completed a randomized, counterbalanced crossover study involving two conditions: sleeping for 8 h at home or in the laboratory. The following morning, participants performed bench press and back squat strength tests across 25-90%1RM, followed by muscular endurance tests to failure at 65%1RM.
Who can participate
Age range
18 Years – 40 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age between 18 and 35 years.• Body Mass Index (BMI) \< 25 kg/m².
* Resistance-trained individuals (more than 2 years of structured training).
* Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from exercising.
* Participants must be able to perform the tests described in the following section.
Exclusion Criteria:
* History of neuromuscular diseases, heart disease, or conditions that may affect liver or muscle metabolism.
* Use of drugs, stimulants, or sports supplements that could interfere with the dietary supplement used in the study.
* Sedentary habits (less than 150 minutes/week of moderate exercise).• Having undergone prolonged periods of physical inactivity in the 6 months prior to the study.
* Engaging in strenuous exercise within 48 hours prior to the tests.• Failure to replicate the same food intake on both experimental days.
* Consumption of caffeine or any other stimulant the day before the tests.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Mean velocity at different %1RM
Timeframe: Through study completion, an average of 3 weeks
2
Number of repetitions performed during 1 set at 65%1RM until task failure
Timeframe: Through study completion, an average of 3 weeks
3
Bar velocity deplacement performed in 1 set at 65%1RM until task failure
Timeframe: Through study completion, an average of 3 weeks
4
Handgrip and isometric mid-thigh pull tests
Timeframe: Through study completion, an average of 3 week
5
Vertical Jump test (CMJ)
Timeframe: Through study completion, an average of 3 week