The Effects of Tyrosol and Creatine on Exercise Performance and Cognition in Healthy Adults (NCT07756658) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
The Effects of Tyrosol and Creatine on Exercise Performance and Cognition in Healthy Adults
United States60 participantsStarted 2026-08-17
Plain-language summary
This study will be a randomized, double-blind, placebo-controlled trial. It will be conducted over a 8-week intervention investigating the effects of creatine (5g Creatine monohydrate); placebo control (5g resistant dextrin), and a combination group containing both creatine and tyrosol (5g creatine monohydrate + 150mg tyrosol/day). Endurance, strength, cognition, and fatigue resistance will be examined through repeated strength and endurance testing (described below).
Participants who pass initial screening will be invited on-site for day one (Visit 1) of testing where they will proceed with a series of tests which will include the following: (1) body composition; (2) mood and cognitive testing; (3) full-body strength testing; (4) 5RM (repetition maximum) bench press, leading to multiple sets of bench press (based on the previous weight) completed to failure; (5) finally, a time to exhaustion endurance test will be conducted followed by (6) repeat cognitive testing.
After the 8-week supplementation period (\~56-60 days), all original measures will be repeated as before in the same order (Visit 2). Approximately 24 hours later (Visit 3) participants will complete a questionnaire for muscle soreness remotely, and again at 48 hours post-Visit 2 (visit 4).
Who can participate
Age range
20 Years – 55 Years
Sex
MALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Healthy males aged 20-55
* Currently active (engaged in moderate to vigorous activity at least 2-days per week as defined by the American College of Sports Medicine Guidelines)
* Estimated VO2 max greater than the 40th percentile of the population norm for age (assessed via ACSM guidelines, 2014). The VO2 max estimation at screening will be obtained by following a non-exercise regression model validated and described by Bradshaw et al. (2005).
* Able to read and write in English
* During the study, agree not to take any other supplements that may increase muscle strength or endurance (e.g. protein formulas, creatine, amino acids, tyrosol or stimulants other than caffeine).
* During the study, subjects will not deviate from their normal daily routine unless it conflicts with study criteria. This includes maintaining their present workout routine and diet, without substantial changes.
Exclusion Criteria:
* Known diagnosis of any cardiovascular, metabolic, endocrine, or renal disease
* Uncontrolled stage II hypertension or higher
* Recent musculoskeletal injury (\<3-months)
* Recent orthopaedic surgery (\<12-months)
* History of or current malignancy
* Previous gastrointestinal surgery within the past 12 months
* Regular smoker
* Regular drinker (\>14 drinks per week)
* Current use (within the past 5 weeks) of creatine supplements
* Current use (within past 3 months) of Tyrosol supplementation
* Current use of dietary supplements that may enhance mitocho…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Mid Thigh Pull
Timeframe: Performed one time at baseline (visit 1) and at day 56 (visit 2)
2
Bench Press 5 Repetition Max (RM)
Timeframe: Performed one time at baseline (visit 1) and at day 56 (visit 2).
3
Bench Press Repetitions to Failure
Timeframe: Performed one time at baseline (visit 1) and at day 56 (visit 2).
4
Muscle/aerobic endurance (Graded Cycling time to exhaustion)
Timeframe: Performed one time at baseline (visit 1) and at day 56 (visit 2).