Active — Not RecruitingNot Applicable

Guangzhou Preterm and Term Birth Cohort Study

China200 participantsStarted 2023-11-21

Plain-language summary

The Guangzhou Preterm-Term Birth Cohort (GPTBC) is a prospective observational study of how early-life nutrition, environmental exposures, and family factors relate to the health and development of preterm and term infants and their mothers. Mother-infant pairs are followed from birth to 24 months. Researchers use questionnaires and biological samples to study human milk, microorganisms in the infant gut, physical growth, development, and allergic diseases, and whether these relationships differ between preterm and term infants. Findings may inform nutrition and health strategies for infants born at different gestational ages.

Who can participate

Age range

18 Years – 45 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Maternal age between 18 and 45 years.
. Resident in Guangzhou for at least one year.
. Gestational age at delivery ≥ 32 weeks and \< 42 weeks (moderate-to-late preterm or term births).

Exclusion criteria

. Critical illness during pregnancy requiring admission to the intensive care unit.
. Unwilling or unable to breastfeed.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Offspring Length/Height (cm)

Timeframe: Birth, 1 months, 3 months, 6 months, 8 months, 12 months, 18 months, and 24 months of age.

Offspring Weight (kg)

Timeframe: Birth, 1 month, 3 months, 6 months, 8 months, 12 months, 18 months, 24 months of age.

Offspring Head Circumference (cm)

Timeframe: Birth, 1 month, 3 months, 6 months, 8 months, 12 months, 18 months, 24 months of age.

Offspring Body Mass Index (kg/m²)

Timeframe: Birth, 1 month, 3 months, 6 months, 8 months, 12 months, 18 months, 24 months of age.

Neurodevelopmental outcome - Gesell Developmental Schedules (GDS)

Timeframe: 1 month, 3 months, 6 months, 8 months, 12 months, 18 months, and 24 months of age.

Neurodevelopmental outcome - Ages and Stages Questionnaires (ASQ)

Timeframe: 1 month, 3 months, 6 months, 8 months, 12 months, 18 months, 24 months of age.

Trial details

NCT IDNCT07756177

SponsorSun Yat-sen University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-12-31

View on ClinicalTrials.gov More Preterm Birth trials

Plain-language summary

Who can participate

Age range

18 Years – 45 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Maternal age between 18 and 45 years.
. Resident in Guangzhou for at least one year.
. Gestational age at delivery ≥ 32 weeks and \< 42 weeks (moderate-to-late preterm or term births).

Exclusion criteria

. Critical illness during pregnancy requiring admission to the intensive care unit.
. Unwilling or unable to breastfeed.

What they're measuring

Offspring Length/Height (cm)

Timeframe: Birth, 1 months, 3 months, 6 months, 8 months, 12 months, 18 months, and 24 months of age.

Offspring Weight (kg)

Timeframe: Birth, 1 month, 3 months, 6 months, 8 months, 12 months, 18 months, 24 months of age.

Offspring Head Circumference (cm)

Timeframe: Birth, 1 month, 3 months, 6 months, 8 months, 12 months, 18 months, 24 months of age.

Offspring Body Mass Index (kg/m²)

Timeframe: Birth, 1 month, 3 months, 6 months, 8 months, 12 months, 18 months, 24 months of age.

Neurodevelopmental outcome - Gesell Developmental Schedules (GDS)

Timeframe: 1 month, 3 months, 6 months, 8 months, 12 months, 18 months, and 24 months of age.

Neurodevelopmental outcome - Ages and Stages Questionnaires (ASQ)

Timeframe: 1 month, 3 months, 6 months, 8 months, 12 months, 18 months, 24 months of age.