CompletedNot Applicable

Salivary Gasdermin E and Granzyme B Levels in Patients With Periodontitis

Turkey (Türkiye)46 participantsStarted 2026-06-11

Plain-language summary

This observational study aims to compare salivary Gasdermin E and Granzyme B levels between individuals with periodontitis and periodontally healthy individuals. It will also evaluate the relationships between these biomarkers and clinical periodontal measurements. Saliva samples and periodontal clinical measurements will be collected from all participants. No treatment or experimental intervention will be administered as part of the study. The findings may contribute to a better understanding of the inflammatory mechanisms associated with periodontitis.

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Individuals aged 18 to 65 years * Presence of at least 20 natural teeth, excluding third molars * Being systemically healthy * Provision of written informed consent * For the periodontitis group, diagnosis of generalized Stage III Grade B periodontitis according to the 2017 AAP/EFP classification * Clinical attachment loss of at least 2 mm at two or more non-adjacent teeth for the periodontitis group * Interdental clinical attachment loss of at least 5 mm and periodontitis-related loss of no more than four teeth for Stage III periodontitis * A radiographic bone loss-to-age ratio between 0.25 and 1.00 for Grade B periodontitis * For the healthy control group, an intact periodontium, probing depth of 3 mm or less, and bleeding on probing at less than 10% of sites Exclusion Criteria: * Use of antibiotics, antimicrobial agents, nonsteroidal anti-inflammatory drugs, steroids, immunosuppressants, beta-blockers, calcium channel blockers, anticoagulants, or hormonal contraceptives within the previous 3 months * Periodontal treatment within the previous 6 months * Surgical periodontal treatment within the previous 12 months * Current smoking * Pregnancy or breastfeeding * Presence of any neurological, autoimmune, metabolic, inflammatory, or other systemic condition that could affect the immune response * Use of an orthodontic appliance

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Salivary Gasdermin E Concentration

Timeframe: At baseline (single study visit)

Salivary Granzyme B Concentration

Timeframe: At baseline (single study visit)

Trial details

NCT IDNCT07755228

SponsorMedipol University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-08-04

View on ClinicalTrials.gov More Periodontitis trials