The Value of Pretreatment With Letrozole on Induction Time of Medical Evacuation With Misoprostol… (NCT07753655) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
The Value of Pretreatment With Letrozole on Induction Time of Medical Evacuation With Misoprostol in Cases of Missed Abortion
74 participantsStarted 2026-08-15
Plain-language summary
The aim is to evaluate the effect of letrozole pretreatment on the induction time during medical evacuation using misoprostol in women diagnosed with missed abortion, and to compare its efficacy and safety to misoprostol alone.
Who can participate
Age range
18 Years – 45 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Women aged 18 - 45 years.
* Diagnosed with missed abortion confirmed by ultrasound (absent fetal heartbeat and/or no embryonic development).
* Gestational age ≤ 12 weeks based on last menstrual period
* Hemoglobin levels \>10 g/dL.
* BMI ranging from 25 to 35 kg/m2.
* Hemodynamically stable and no signs of infection.
Exclusion Criteria:
* Incomplete abortion, inevitable abortion, or threatened miscarriage.
* Suspected ectopic pregnancy and molar pregnancy.
* History of allergy or contraindication to misoprostol or letrozole.
* Coagulopathy or use of anticoagulant medications.
* Chronic medical diseases (e.g., uncontrolled diabetes, cardiovascular disease, liver or renal dysfunction).
* Prior uterine surgery that contraindicates medical abortion (e.g., classical cesarean section, myomectomy with uterine entry).
* Uterine anomalies.
* Women unsure of LMP
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Time of complete uterine evacuation
Timeframe: one week following Misoprostol administration