Effects of Curcumin-Piperine Supplementation in Fibromyalgia (NCT07753018) | Clinical Trial Compass
Not Yet RecruitingPhase 2
Effects of Curcumin-Piperine Supplementation in Fibromyalgia
Egypt80 participantsStarted 2026-08-01
Plain-language summary
The goal of this clinical trail is to evaluate the effectiveness and safety of curcumin-piperine supplementation in patients with fibromyalgia over 3 months compared to placebo.
Participants will:
Be randomly assigned to receive either curcumin and piperine supplements or a placebo.
Attend scheduled clinic visits for clinical assessments and blood sample collection.
Complete study questionnaires before and after treatment time frame.
The primary question the study aim to answer is:
Does Curcumin-piperine supplementation reduce pain intensity by Visual Analog Scale (VAS), compared with placebo?
The secondary questions this study aims to answer are:
Does supplementation improve fibromyalgia disease impact and quality of life? Does supplementation improve inflammatory biomarkers and oxidative stress? Does supplementation improve insulin resistance? Is curcumin and piperine supplementation safe and well tolerated?
Who can participate
Age range
18 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult women aged ≥18 years.
* Patients with confirmed diagnosis of fibromyalgia, according to 2022 ACR Fibromyalgia criteria.
Exclusion Criteria:
* Diabetic patients (HbA1c ≥ 6.5).
* Patients with chronic inflammatory or autoimmune diseases other than FM.
* Patients allergic to curcumin or piperine.
* Patients receiving other anti-inflammatory medications.
* Severe hepatic or renal impairment.
* Patients receiving anticoagulant medications (e.g., clopidogrel).
* Pregnancy or lactation.
* Participation in another clinical trial
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Assessment of pain severity measured by the Visual Analog Scale (VAS)