Fractional CO₂ Laser Before Follicular Unit Extraction Hair Transplantation With Platelet-Rich Pl… (NCT07751523) | Clinical Trial Compass
CompletedNot Applicable
Fractional CO₂ Laser Before Follicular Unit Extraction Hair Transplantation With Platelet-Rich Plasma for Secondary Cicatricial Alopecia
Egypt20 participantsStarted 2024-05-02
Plain-language summary
Secondary cicatricial alopecia is characterized by permanent hair loss due to destruction of hair follicles following trauma, burns, infection, or other causes. Hair transplantation using follicular unit extraction (FUE) is an established treatment; however, graft survival may be limited by poor vascularity and fibrosis within scar tissue. Fractional carbon dioxide (CO₂) laser has been proposed to improve the recipient site by enhancing tissue remodeling and vascularization before transplantation.
This prospective comparative clinical study evaluated the effect of three preoperative sessions of fractional CO₂ laser followed by FUE hair transplantation with intraoperative platelet-rich plasma (PRP) injection compared with FUE hair transplantation combined with intraoperative PRP alone in patients with stable secondary cicatricial alopecia. Twenty participants were allocated into two groups of 10 patients each and were followed for 9 months after hair transplantation.
The primary objective was to determine whether preoperative fractional CO₂ laser improves the clinical outcome of FUE hair transplantation in secondary cicatricial alopecia. Outcomes included clinical improvement, dermoscopic assessment of hair growth, patient satisfaction, and scar assessment.
Who can participate
Age range
16 Years – 30 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients with stable secondary cicatricial alopecia. Male or female participants. Participants with realistic expectations regarding treatment outcomes. All hair types (silky, curly, or normal hair). Presence of an adequate donor site for follicular unit extraction (FUE). Ability and willingness to provide written informed consent.
Exclusion Criteria:
* Extremes of age. Chronic systemic diseases, including hepatic or renal disease. Receiving chemotherapy or systemic corticosteroid therapy. Platelet disorders or other blood disorders. Pregnancy or lactation. History of keloid formation. Scar duration less than 1 year. Absence of a suitable donor site for hair transplantation
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Clinical improvement after hair transplantation
Timeframe: 9 months after follicular unit extraction (FUE) hair transplantation