Effects of Low-Level Laser Therapy and Hyaluronic Acid After Free Gingival Graft (NCT07751211) | Clinical Trial Compass
CompletedNot Applicable
Effects of Low-Level Laser Therapy and Hyaluronic Acid After Free Gingival Graft
Turkey (Türkiye)30 participantsStarted 2025-11-06
Plain-language summary
The goal of this randomized clinical trial was to learn whether low-level laser therapy or hyaluronic acid application improves healing after free gingival graft surgery in adults with insufficient keratinized gingival tissue in the mandibular lower teeth region.
The main questions it aimed to answer were:
* Do low-level laser therapy and hyaluronic acid application reduce shrinkage of the gingival graft?
* Do these treatments reduce postoperative pain and pain medication use and improve wound healing, clinical outcomes, appearance, and oral health-related quality of life?
Researchers compared three groups: free gingival graft surgery alone, free gingival graft surgery with low-level laser therapy and free gingival graft surgery with hyaluronic acid application.
Participants underwent free gingival graft surgery and were followed for six months. During follow-up, researchers measured graft size and shrinkage, periodontal clinical measurements, pain at the donor and recipient sites, pain medication use, wound healing, esthetic outcomes, and oral health-related quality of life.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Voluntary participation and provision of written informed consent
* Systemically healthy adults aged 18 years or older
* Non-smokers
* No known drug allergies
* Not pregnant or breastfeeding
* Presence of Cairo RT1 or RT2 gingival recession in the mandibular anterior region
* Keratinized tissue width of less than 2 mm at the planned grafting site
* Plaque Score below 20% and Bleeding on Probing score below 20%
* Vital teeth in the surgical area
Exclusion Criteria:
* Current use of medications that may interfere with wound healing or are contraindicated for surgical procedures
* Pregnancy or breastfeeding
* Ongoing orthodontic treatment in the affected region
* History of previous periodontal surgery in the study area
* Presence of active periodontal disease
* Probing pocket depth greater than 3 mm in the involved teeth
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.