CompletedNot Applicable

Derivation and External Validation of the "FORECAST-PC" Prediction Scores

Switzerland732 participantsStarted 2015-01-01

Plain-language summary

This study aims to develop and externally validate machine learning prediction models (FORECAST-PC) to determine 90-day functional outcomes for patients suffering from acute ischemic stroke in the posterior circulation who are selected for endovascular thrombectomy (EVT)

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age \> 18 years * Presentation with acute ischemic stroke (AIS) attributed to a radiologically confirmed posterior circulation occlusion * Selected for Endovascular Thrombectomy (EVT) according to the treating physician * Pre-stroke modified Rankin Scale (mRS) 0-3 * EVT initiated or attempted within 24-hours of the last known well (LKW) time * Includes cases with/without prior intravenous thrombolysis (IVT), mothership, and drip-and-ship pathways Exclusion Criteria: * EVT carried out beyond 24 hours from stroke onset * EVT performed secondarily after in-hospital worsening or stroke recurrence * In-hospital strokes (to avoid the confounding influence of prior systemic comorbidities and the acute event that necessitated initial admission) * Missing primary outcome data * Inconsistencies between descriptive dependence status and raw pre-stroke mRS * Stroke cases occurring prior to 2015 (to account for major changes in endovascular treatment techniques)

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Unfavorable Functional Outcome at 90 Days

Timeframe: 90 days

Trial details

NCT IDNCT07750015

SponsorDr. med. Alexander Salerno, MD-PhD

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-12-31

View on ClinicalTrials.gov More Posterior Ischemic Stroke trials

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.