Comparison Between Low-Dose and High-Dose Nepafenac Sodium (NCT07749027) | Clinical Trial Compass
CompletedNot Applicable
Comparison Between Low-Dose and High-Dose Nepafenac Sodium
Pakistan176 participantsStarted 2026-01-01
Plain-language summary
In South Punjab, Pakistan, where tertiary hospitals manage a high cataract workload, data on nepafenac sodium to reduce this inflammatory response is not up to the mark. Relative benefit of low-dose versus high-dose regimens remains unclear in routine clinical practice. Therefore, this study was performed with the objective to compare the effectiveness of low-dose nepafenac sodium with high-dose nepafenac sodium in preventing macular edema after cataract surgery.
Who can participate
Age range
18 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Any gender
* Aged 18-60 years
* Planned for cataract surgery
Exclusion Criteria:
* Patients with clinical or optical coherence tomography (OCT) evidence of pre-existing macular edema
* Uncontrolled hypertension
* Diabetes mellitus
* Previous stroke
* Renal failure
* Ischemic heart disease with unstable symptoms
* Acute or chronic uveitis
* Retinitis pigmentosa
* Diabetic retinopathy
* Age-related macular degeneration
* Epiretinal membrane
* Retinal vein occlusion
* Glaucoma
* History of intraocular surgery
* Traumatic cataract
* Hypersensitivity to nepafenac or other non-steroidal anti-inflammatory drugs
* Using topical or systemic anti-inflammatory drugs before surgery
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.