CompletedNot Applicable

Photon-Counting CT for Detection of Small Gastrointestinal Lesions

China1,762 participantsStarted 2023-09-18

Plain-language summary

This comparative matched-cohort study aims to evaluate the diagnostic performance of contrast-enhanced photon-counting computed tomography (PCCT) for detecting small gastrointestinal lesions compared with energy-integrating detector dual-energy computed tomography (DECT). The study includes a prospectively enrolled PCCT cohort and a retrospectively identified DECT cohort. Endoscopy with histopathology serves as the reference standard. Primary evaluation focuses on lesion detection, with additional assessment of lesion characterization, image quality, quantitative imaging parameters, and interobserver agreement.

Who can participate

Age range

18 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Adults aged 18-80 years.
. Patients undergoing contrast-enhanced abdominal CT (photon-counting CT or energy-integrating detector dual-energy CT).
. At least one endoscopically detected or clinically suspected small gastrointestinal lesion.
. Lesions confirmed or suspected on endoscopy, pathology, or follow-up imaging.
. Lesions characterized as mucosal thickening or nodular lesions within predefined size criteria (≤2 cm).

Exclusion criteria

. Prior gastrointestinal surgery affecting target evaluation region.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Lesion-Based Detection Rate

Timeframe: During the study period (January 2026 - March 2026)

Trial details

NCT IDNCT07748923

SponsorThe Second Affiliated Hospital of Chongqing Medical University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-01-09

View on ClinicalTrials.gov More Gastrointestinal Lesions trials