Effect of Titanium-Prepared Platelet-Rich Fibrin and Low-Level Laser Therapy on Postoperative Mor… (NCT07748585) | Clinical Trial Compass
CompletedNot Applicable
Effect of Titanium-Prepared Platelet-Rich Fibrin and Low-Level Laser Therapy on Postoperative Morbidity After Mandibular Third Molar Surgery
Turkey (Türkiye)60 participantsStarted 2025-12-27
Plain-language summary
This randomized double-blind clinical trial aims to evaluate the effects of titanium-prepared platelet-rich fibrin (T-PRF), low-level laser therapy (LLLT), and their combination on postoperative outcomes following surgical extraction of impacted mandibular third molars. Sixty patients will be randomly allocated to one of four parallel groups: T-PRF, LLLT, T-PRF plus LLLT, or control. The primary outcomes include postoperative pain assessed using a visual analogue scale (VAS), analgesic consumption, postoperative swelling and trismus. The findings may help identify effective approaches for improving postoperative recovery after mandibular third molar surgery.
Who can participate
Age range
18 Years – 31 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults requiring surgical extraction of a unilateral vertically impacted mandibular third molar.
* Healthy individuals (ASA I or II).
* Ability to provide written informed consent.
* Willingness to attend all follow-up visits.
Exclusion Criteria:
* Systemic disease affecting wound healing.
* Pregnancy or lactation.
* Active infection or acute pericoronitis.
* Long-term opioid use.
* Smoking and alcohol use.
* Known allergy to study medications.
* Previous radiotherapy to the head and neck region
* Inability to attend follow-up visits.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Postoperative Pain
Timeframe: Postoperative Days 1, 2, 3, and 7
2
Analgesic Consumption
Timeframe: Postoperative Days 1, 2, 3, and 7
3
Facial Swelling
Timeframe: Preoperative baseline and Postoperative Days 1, 2, 3, and 7
4
Maximum Interincisal Mouth Opening (Trismus)
Timeframe: Preoperative baseline and Postoperative Days 1, 2, 3, and 7
Trial details
NCT IDNCT07748585
SponsorNEW Cyprus Health and Social Sciences University