Not Yet RecruitingNot Applicable

Comparison of Post-operative Pain and Levels of MMP -9 Following Root Canal Irrigation With Sodium Hypochlorite Versus Cold Atmospheric Plasma in Patient With Necrotic Single Rooted Teeth: Randomized Clinical Trial

Egypt60 participantsStarted 2026-08

Plain-language summary

The goal of this clinical trial is to compare the effect of cold atmospheric plasma versus sodium hypochlorite as irrigating solutions in necrotic single rooted teeth. The main questions it aims to answer are: * Does the use of sodium hypochlorite solution or cold atmospheric plasma as root canal irrigant will have the same effect on the level of postoperative pain in necrotic single rooted teeth? * Does the use of sodium hypochlorite solution or cold atmospheric plasma as root canal irrigant will have the same effect on the level of MMP -9 in necrotic single rooted teeth? Researchers will compare cold atmospheric plasma to sodium hypochlorite solution as root canal irrigant to see if cold atmospheric plasma works to have the same effect on the level of postoperative pain and levels of MMP -9 in necrotic single rooted teeth. Participants will: * be asked to rate their pain level according to the given instructions and will be asked to return for follow up after 2 days to hand the pain scale chart. * be instructed to call the operator and will be permitted to take Ibuprofen 400 mg not more than 6 hours apart and to record their tablet intake within 48 hours postoperatively, in case of severe or persistent pain. * be referred to the fixed prosthodontics department for final restoration.

Who can participate

Age range

18 Years – 55 Years

Sex

ALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Patients in good physical health; American Society of Anesthesiologists (ASA) class I or II, with no known allergic manifestations to the drugs used in the study and no involvement with other medication during the study (Appendix)
. Patient's age between 18-55 years.
. Male and female patients.
. Patients who can understand the numerical rating scale (Appendix 4).
. Patients who accept to participate in the trial and can sign the informed consent (Appendix 1).
. Mature mandibular premolar teeth with:

Exclusion criteria

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Post-operative pain

Timeframe: 6,12,24,48 hours and 7 days postoperative following the two visits.

Trial details

NCT IDNCT07747753

SponsorAhmed Hesham Abdelmohaimen Rezk

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-01

Contact for this trial

Manar Yosri Fouda, Professor

002 01001101108 manaryfouda@gmail.com

View on ClinicalTrials.gov More Necrotic Pulp trials