CompletedNot Applicable

Gingival Graft vs T-PRF in Papilla Defects

Turkey (Türkiye)34 participantsStarted 2022-11-15

Plain-language summary

Objective: Titanium-prepared platelet-rich fibrin (T-PRF) has emerged as a promising biomaterial in periodontal regenerative procedures. The aim of this study will be to compare the clinical effectiveness of de-epithelialized gingival grafts (DGG) and T-PRF in the reconstruction of deficient interdental papillae using the tunnel technique. Methods: A total of 34 patients presenting with 115 Class I and II interdental papilla defects will be enrolled in this study. Interdental papilla reconstruction will be performed using the tunnel technique in combination with either DGG or T-PRF. Demographic characteristics (age and sex), dentogingival variables (tooth shape, papilla location, jaw type, and papilla loss classification), and clinical parameters will be recorded. Clinical assessments will include probing depth (PD), gingival index (GI), plaque index (PI), gingival thickness (GT), keratinized tissue height (KTH), black triangle width (BTW), black triangle height (BTH), papilla fill percentage (%PF), and black triangle area (BTA). All clinical parameters will be assessed at baseline and at 1, 3, and 6 months following surgery.

Who can participate

Age range

25 Years – 75 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age between 25 and 70 years. * Presence of papilla loss in the anterior region of the maxilla or mandible. * Classification of papilla loss as Class 1 or 2 * Absence of systemic diseases. * No bleeding disorders that could interfere with the surgery. * Non-smoker and non-alcohol consumer. * Not pregnant or breastfeeding. * Absence of fillings, prostheses, or root canal treatments in the relevant teeth. * No prior surgical interventions in the target area. Exclusion Criteria: * Smoking or alcohol consumption. * Presence of systemic diseases * Patients who did not attend postoperative follow-up appointments regularly. * Pregnant or breastfeeding individuals.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

black triangle height

Timeframe: preoperative and postoperative (1, 3, 6 months)

black triangle width

Timeframe: preoperative and postoperative (1, 3, 6 months)

black triangle area

Timeframe: preoperative and postoperative (1, 3, 6 months)

% Percentage fill

Timeframe: preoperative and postoperative 6 months

Trial details

NCT IDNCT07746622

SponsorPamukkale University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-02-14

View on ClinicalTrials.gov More Papilla Reconstruction trials

Plain-language summary

Who can participate

Age range

25 Years – 75 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

black triangle height

Timeframe: preoperative and postoperative (1, 3, 6 months)

black triangle width

Timeframe: preoperative and postoperative (1, 3, 6 months)

black triangle area

Timeframe: preoperative and postoperative (1, 3, 6 months)

% Percentage fill

Timeframe: preoperative and postoperative 6 months