Efficacy of Bioactive Collagen Peptide Compared to Glucosamine and Chondroitin Sulphate in Grade … (NCT07746466) | Clinical Trial Compass
CompletedNot Applicable
Efficacy of Bioactive Collagen Peptide Compared to Glucosamine and Chondroitin Sulphate in Grade I-III Knee Osteoarthritis
Pakistan150 participantsStarted 2023-06-01
Plain-language summary
Brief Summary
The goal of this clinical trial is to learn whether bioactive collagen peptide works as well as glucosamine and chondroitin sulphate for improving pain, stiffness, physical function, and quality of life in adults with mild to moderate knee osteoarthritis (Kellgren-Lawrence grades I to III).
The main questions it aims to answer are:
Does bioactive collagen peptide improve knee pain, stiffness, and physical function over 12 weeks? Does bioactive collagen peptide improve health-related quality of life? Is bioactive collagen peptide as safe and effective as glucosamine and chondroitin sulphate for treating knee osteoarthritis?
Researchers will compare bioactive collagen peptide with glucosamine and chondroitin sulphate to determine whether one treatment provides greater improvement in symptoms and quality of life.
Participants will:
Be randomly assigned to receive either bioactive collagen peptide once daily or glucosamine and chondroitin sulphate twice daily for 12 weeks.
Attend study visits at the start of the study and again at 6 and 12 weeks. Complete questionnaires about their knee pain, stiffness, physical function, and overall health-related quality of life at each visit.
Be monitored for treatment adherence, use of rescue pain medication, and any side effects throughout the study.
The information from this study may help healthcare providers better understand whether bioactive collagen peptide is an effective and safe non-surgical treatment option for people with symptomatic knee osteoarthritis.
Who can participate
Age range
40 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults aged 40 years and older.
* Clinical diagnosis of knee osteoarthritis according to the American College of Rheumatology (ACR) criteria.
* Radiographic Kellgren-Lawrence grade I, II, or III osteoarthritis in at least one knee.
* Willing and able to provide written informed consent.
* Willing to comply with the study protocol and attend all follow-up visits.
Exclusion Criteria:
* Inflammatory arthritis, including rheumatoid arthritis, systemic lupus erythematosus, spondyloarthropathy, or polymyalgia rheumatica.
* Post-traumatic osteoarthritis.
* Patients with hyperuricemia.
* Pregnancy or breastfeeding.
* Previous use of collagen peptide or glucosamine-chondroitin supplements before enrollment.
* Inability or unwillingness to comply with study procedures or complete follow-up.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial compared bioactive collagen peptides to glucosamine and chondroitin sulphate for Grade 1–3 knee osteoarthritis — given my specific Kellgren-Lawrence grade, which of these approaches, if any, does the evidence from this study suggest might be worth discussing for my situation?
2The trial measured changes in the WOMAC score and quality of life using the EQ-5D-5L — can you walk me through what those outcome measures actually mean in practical terms, like how much pain relief or improved daily function patients in this study actually experienced?
3Since this trial is listed as Phase NA and involved a supplement comparison rather than a drug, what does that mean for how confident we can be in the safety and effectiveness of bioactive collagen peptides compared to the glucosamine and chondroitin I might already be familiar with?
4Now that this trial is completed, are the full results published or available anywhere, and should I be considering either of these supplements as part of my treatment plan or would standard care options like physical therapy or prescription treatments be a better first step for me?
5If I have Grade 2 or 3 osteoarthritis like some participants in this trial, are supplements like these typically used alongside other treatments or as a replacement, and how would my doctor know if one approach is actually working for me?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Total Score
Timeframe: From baseline to 6 weeks and from 6 weeks to 12 weeks (Total 3 months)
2
Change in Health-Related Quality of Life (EQ-5D-5L)
Timeframe: From baseline to 6 weeks and from 6 weeks to 12 weeks (Total 12 weeks/3months)
Trial details
NCT IDNCT07746466
SponsorLiaquat National Hospital & Medical College