Effects of Exercise Prior to Radical Prostatectomy (NCT07746414) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Effects of Exercise Prior to Radical Prostatectomy
United States20 participantsStarted 2026-08
Plain-language summary
This pilot study will explore the metabolic and psychological effects of High-Intensity Interval Training (HIIT) exercise as well as its impact on patient recovery from radical prostatectomy.
Who can participate
Age range
35 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Scheduled or intended treatment with radical prostatectomy at Yale New Haven Hospital
* English language fluency
* Clinically localized low, intermediate or high risk by National Comprehensive Cancer Network (NCCN) criteria
* Able to attend 2 in person exercise training sessions per week for four-six weeks
Exclusion Criteria:
* Treatment with non-surgical modality
* Prior therapy for prostate cancer (e.g. radiation therapy or focal therapy)
* Already engaged in regular exercise (\>60 minutes per week)
* Unstable cardiovascular disease
* Physical mobility limitation, unable to walk or exercise
* Locally advanced (cT4 or cN1 or cM1) prostate cancer
* Prior treatment with androgen deprivation therapy
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is looking at a molecule called N-lactoyl phenylalanine as a way to measure the effects of exercise before prostate surgery — can you explain what that marker actually tells us about recovery, and why it might matter for my situation?
2Since this trial isn't recruiting yet, how long do you think it might be before it opens, and should I be thinking about starting treatment now or is it reasonable to wait and see if I might be eligible?
3The trial focuses on exercise done before a radical prostatectomy — what does the current evidence say about prehabilitation, and is there anything I could safely be doing now regardless of whether I join a study?
4Because this trial doesn't have a traditional phase number, what does that mean for how much is already known about the safety and benefits of the exercise program being tested?
5If I'm not able to participate in this trial for any reason, are there other ways you'd recommend I prepare my body before prostate surgery to support a better recovery afterward?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Mean concentration N-lactoyl phenylalanine
Timeframe: Pre-exercise (Baseline) and post-excercise (4 weeks)