RecruitingEarly Phase 1

Local Application of Insulin Versus Hyaluronic Acid in Stage III Periodontitis

Egypt45 participantsStarted 2026-07-24

Plain-language summary

The present study will be performed on fourty-five patients suffering from periodontitis according to the criteria of American academy of periodontology to evaluate clinically effect of topical application of insulin versus hyaluronic acid as an adjunct to non surgical periodontal therapy in stage Ⅲ periodontitis patients. This will be done by: 1. Clinical assessment. 2. Biochemical analysis. - Dose the topical application of insulin or hyaluronic acid as an adjunct to non-surgical periodontal therapy improves periodontal condition in stage Ⅲ periodontitis patients? PICO P (Population): patients with stage Ⅲ periodontitis. I (Intervention): non surgical periodontal therapy (SRP) with topical application using insulin or hyaluronic acid in periodontal pockets. C (Comparison): topical application of insulin versus hyaluronic acid and SRP alone in periodontal pocket. O (Outcome): primary outcome: change in periodontal pocket depth (PPD) or clinical attachment loss (CAL). Secondary outcome: change in gingival index (GI) or bleeding on probing index (BOP) and levels of IL-1β in GCF of treated pocket. Study type: Randomized controlled trials (RCTs).

Who can participate

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * All selected patients are free from systemic illness as evaluated according to dental modification of the Cornell medical index. * Should be diagnosed as having periodontitis. * Not received any type of periodontal treatment in the past 6 months prior to examination. * Should be cooperative, motivated, and willing to follow our treatment protocol and follow up visits. * Not received antibiotics or anti-inflammatory therapy in the 6 months prior to examination. Exclusion Criteria: * Antibiotic therapy in the preceding 6 months or during study participation. * History of insulin dependent diabetes and thyroid disease. * Pregnancy, smoking, chronic diseases such as diabetes mellitus or rheumatoid arthritis, and allergy to ingredients in the drug. * Poor oral hygiene compliance or inability to adhere to the clinical protocol.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Periodontal pocket depth (PPD)

Timeframe: 3-6 months

Clinical attachment loss (CAL)

Timeframe: 3-6 months

Trial details

NCT IDNCT07746206

SponsorDoaa Atta Aid

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2026-07-25

View on ClinicalTrials.gov More Treatment of Stage III Periodontitis trials

Plain-language summary

Who can participate

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.