RESTORE-BLADDER (REgistry on STrategies for Organ pREservation in Muscle-invasive BLADDER Cancer) (NCT07744958) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
RESTORE-BLADDER (REgistry on STrategies for Organ pREservation in Muscle-invasive BLADDER Cancer)
100 participantsStarted 2026-09
Plain-language summary
Removal of the urinary bladder (radical cystectomy) is a major surgical procedure that can have a permanent impact on a patient's quality of life. Consequently, some patients, despite having received comprehensive counseling and completing systemic therapy, decide against subsequent surgery or alternative radiotherapy. Recent scientific studies suggest that, for selected patients, an attempt at bladder preservation may be a medically justifiable option. However, it remains unclear which patients are truly suitable candidates for bladder-preserving management and which are not. The aim of this registry is therefore to collect and analyze clinical data from this specific patient population.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients aged \>= 18 years, capable of providing informed consent
* Histologically confirmed muscle-invasive urothelial carcinoma of the urinary bladder
* Received perioperative systemic therapy in accordance with current guidelines and subsequently decline cystectomy or radiotherapy
Exclusion Criteria:
* Age \< 18 years
* Lack of capacity to provide informed consent
* No histological confirmed muscle-invasive urothelial carcinoma
* No prior preoperative systemic therapy
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This is a registry study called RESTORE-BLADDER that's tracking organ preservation strategies for muscle-invasive bladder cancer — can you explain what organ preservation means in my specific situation, and whether trying to keep my bladder is a realistic goal compared to surgical removal?
2Since this trial isn't yet recruiting, how long do you think it might be before it opens, and is there a standard-of-care treatment I should be starting now rather than waiting to see if I can join?
3The main thing this registry is measuring is whether people are free from the cancer spreading at two years — based on my individual case, what does my doctor think my realistic chances of reaching that milestone look like with different treatment approaches?
4Because this is listed as phase N/A and appears to be an observational registry rather than a treatment trial, does participating actually change what treatment I receive, or would I just be contributing data while following a treatment plan my care team already recommends?
5Are there other active clinical trials or established bladder-preserving treatment protocols — like trimodality therapy — that I could access right now while this registry study is still in the pre-recruitment phase?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.