SURPASS-HF was a 90-day, single-center, single-arm, prospective feasibility study asking whether adults with heart failure and an implanted pulmonary artery (PA) pressure sensor can safely share in managing their own diuretic (water pill) dosing. Participants were already implanted with a CardioMEMS PA pressure sensor and managed by a single cardiovascular team using a previously published hemodynamic treatment algorithm. Each participant received a simplified treatment guide (sliding scale) prescribing how to adjust diuretic doses based on their own PA pressure readings, which were relayed to them daily through the Epic MyChart patient portal. Protocol-mandated laboratory testing followed each diuretic adjustment. The study measured safety (hospitalizations, urgent visits, kidney injury, syncope, electrolyte disturbances) and effectiveness (heart failure hospitalizations, average PA diastolic pressure, and how often the care team needed to intervene) over 90 days, with quality of life assessed by the Minnesota Heart Failure Questionnaire. A separate retrospective chart-review cohort of 31 CardioMEMS patients served as a comparison group.
Who can participate
Age range
40 Years – 90 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Currently implanted with and actively transmitting remote pulmonary artery pressures using the CardioMEMS HF system and exclusively managed by the Froedtert Menomonee Falls Cardiovascular Team according to previously published hemodynamic treatment algorithm.
. Provision of signed and dated informed consent
. Stated willingness to comply with study procedure and mandates and remain available for the duration of the study period of 90 days.
. Males and females; Ages 40-90
. Documented diagnosis of heart failure (regardless of ejection fraction) with volume related symptoms managed with a loop diuretic.
. Willingness to participate in a shared-management strategy
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
. Access to necessary resources for participating in a technology-based intervention (i.e., Epic MyChart via computer, smartphone, or tablet with internet access)
Exclusion criteria
. Allergy/intolerance to loop or thiazide diuretics.
. Oliguria/anuria either acute or chronic.
. Chronic kidney disease Stage IV, V, or undergoing renal replacement therapy.
. Transplant organ recipient
. Chronic immunosuppressant therapy
. Idiopathic fluid collections (for example ascites, pulmonary or pericardial effusions)
. Currently undergoing chemotherapy for malignancy or having received chemotherapeutic treatment in the past 12 months.
. Hospice plan of care or prior designation of hospice plan of care within 12 months.