RecruitingNot Applicable

Precision Lifestyle Medicine Program for IFHAS Participants

United Arab Emirates150 participantsStarted 2026-08-03

Plain-language summary

The goal of this clinical trial is to evaluate whether a precision lifestyle medicine intervention can improve cardiometabolic health in Emirati adults aged 25 to 50 years living in Abu Dhabi with obesity (BMI 30-35 kg/m²) who have previously completed IFHAS screening. The study will also use IFHAS screening data to better understand participants' health profiles and the relationship between lifestyle factors and chronic diseases. The main questions it aims to answer are: * Does a precision lifestyle medicine program improve cardiometabolic biomarkers after an 18-week intervention? * Can IFHAS screening data be used to identify health risk profiles and support personalized lifestyle interventions for the Emirati population? Researchers will compare participants receiving the precision lifestyle medicine intervention with a propensity-matched control group receiving standard IFHAS care to determine whether the intervention leads to greater improvements in cardiometabolic health. Participants will: * Take part in an 18-week personalized lifestyle medicine program tailored to their health profile. * Attend study visits and complete health assessments over a total study period of 24 weeks. * Undergo cardiometabolic biomarker assessments before and after the intervention. * Complete questionnaires or assessments about their adherence to the lifestyle program and their experience with the precision lifestyle medicine clinic. * Provide biological samples to support the establishment of a biomarker repository for future research.

Who can participate

Age range

25 Years – 50 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Emiratis residing in Abu Dhabi emirate * Aged 25-50 years * BMI 30-35 kg/m² * Thiqa cardholder * Previous participation in IFHAS screening * Able to provide informed consent * Participant in the Emirati Genome Programme * No weight-loss medications (e.g., Ozempic, Saxenda, Wegovy) within 3 months of enrollment. Exclusion Criteria: * Aged under 25 years or over 50 years of age * BMI range under 30 kg/m2 and over 35 kg/m2 * Taking weight loss medication such as GLP-1 drugs (Ozempic, Saxenda, Wegovy) * Active treatment for serious medical conditions (cancer, planned surgery, immunomodulation) * Transplant surgery within 12 months * Pregnancy * Surgery within 3 months prior to recruitment * Physical limitations preventing exercise participation * Current enrolment in other lifestyle intervention programs * Active psychiatric conditions, cognitive impairment, or mental health conditions affecting study participation * Contraindication to MRI or DEXA imaging, including severe claustrophobia or need for sedation.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in Body Mass Index (BMI)

Timeframe: Baseline and Week 24

Change in Cardiometabolic Composite Response

Timeframe: 24 weeks

Trial details

NCT IDNCT07742917

SponsorInstitute for Healthier Living Abu Dhabi

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-06-13

Contact for this trial

Erik Koornneef, PhD

+971500888594 e.koornneef@ihlad.ae

View on ClinicalTrials.gov More Obese Adults trials