Comparison of PRF and Corticosteroids in Impacted Third Molar Surgery (NCT07742826) | Clinical Trial Compass
RecruitingNot Applicable
Comparison of PRF and Corticosteroids in Impacted Third Molar Surgery
Cyprus60 participantsStarted 2024-09-03
Plain-language summary
This prospective, randomized interventional study aims to compare the postoperative effects of standard treatment (control), platelet-rich fibrin (PRF), and PRF combined with corticosteroid treatment in patients undergoing impacted mandibular third molar surgery. A total of 60 participants will be randomly assigned to one of three treatment groups according to the study protocol. Postoperative pain, facial swelling, and trismus will be evaluated on postoperative days 1, 2, 3, and 7. The findings of this study are expected to provide evidence regarding the effectiveness of PRF alone and PRF combined with corticosteroid treatment in reducing postoperative complications following impacted mandibular third molar surgery.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients aged 18 years and older.
* Patients with good general health
* Patients with complete clinical and radiographic examination (panoramic radiograph/CBCT if applicable)
* Patients willing and able to attend all postoperative follow-up visits
Exclusion Criteria:
* Patients with systemic diseases that may impair wound healing (e.g., uncontrolled diabetes, immunodeficiency).
* Pregnant or breastfeeding women.
* Patients with acute infection, abscess, or pericoronitis at the surgical site.
* Patients with a history of allergy or contraindication to corticosteroids, local anesthetics, or prescribed medications.
* Patients using corticosteroids, anticoagulants, immunosuppressive drugs, or bisphosphonates.
* Patients with bleeding disorders.
* Patients with previous radiotherapy to the head and neck region.
* Patients unable or unwilling to comply with the study protocol or attend follow-up visits.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.