Assessing Treatment With High-phenolic EVOO Supplements for Neurovascular Activity (NCT07741773) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Assessing Treatment With High-phenolic EVOO Supplements for Neurovascular Activity
United States20 participantsStarted 2026-09-01
Plain-language summary
The goal of this clinical trial is to determine whether the extra-virgin olive oil (EVOO) phenolic dietary supplement can improve memory function and modulate biomarkers among individuals with mild cognitive impairment (MCI). The main questions it aims to answer are:
* Does dietary supplementation with EVOO phenolics improve cognitive function?
* What would be the effect of the EVOO dietary supplement on other MCI-related biomarkers, including vascular function and biological pathways?
Researchers will compare the EVOO dietary supplements with a placebo (a look-alike substance that contains no EVOO phenolics)
Participants will:
* Take EVOO dietary supplements or a placebo daily for 6 months
* Visit the study site during the 6-month study for screening and testing.
Who can participate
Age range
50 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* CDR (Clinical Dementia Rating) score of 0.5 OR MoCA (Montreal Cognitive Assessment) score of 18-25.
Exclusion Criteria:
* History or presence of vascular disease that may affect cognitive function
* History or presence of stroke within the past 1 year
* Recent transient ischemic attack (TIA) within the past 180 days
* History of severe, clinically significant CNS trauma
* History of intracranial tumor
* History or presence of kidney disease (eGFR \<60 mL/min/1.73m2)
* Presence of a pacemaker
* Presence of metal in the body
* Allergic to the MRI contrast agent "Multihance"
* Pregnancy
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is listed as 'not yet recruiting' — do you know when it's expected to open, and is it worth waiting for it given where I am in managing my mild cognitive impairment right now?
2The trial is testing a high-phenolic extra virgin olive oil supplement rather than a drug — can you help me understand what risks or unknowns might still exist with this kind of supplement, especially for someone with my health history?
3The study is measuring changes in cerebrovascular blood flow and brain blood vessel function — based on my current test results, do I have any signs of those kinds of changes that might make this trial particularly relevant or irrelevant to my situation?
4Since this trial is listed as Phase NA, which suggests it may be exploratory or early-stage, what does that mean for how much we'd actually know about whether this approach helps people with MCI before I consider participating?
5Are there established treatments or lifestyle changes for mild cognitive impairment that I should be trying first, or could pursuing this trial fit alongside what I'm already doing?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Cerebrovascular function
Timeframe: At baseline and end of treatment (6 months)
2
Cerebrovascular blood flow
Timeframe: At baseline and end of treament (6 months)
3
Cognitive function
Timeframe: At baseline and end of treament (6 months)