Biomarker Analysis Data From a Randomized Phase II Study in Patients With Nasopharyngeal Carcinom… (NCT07741110) | Clinical Trial Compass
CompletedNot Applicable
Biomarker Analysis Data From a Randomized Phase II Study in Patients With Nasopharyngeal Carcinoma Treated With Chemotherapy and Radiotherapy
141 participantsStarted 2003-10-01
Plain-language summary
Clinicopathological and genomic data (Next generation sequencing and IHC/CISH) in available tissues were performed in patients with nasopharyngeal carcinoma who participated in a previously conducted randomized phase II study that evaulated induction chemotherapy followed by CCRT with CCRT alone.
Who can participate
Age range
15 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* biopsy-proven, previously untreated WHO type I, II or III NPC;
* age \> or equal to 15 years
* stage IIB-IVB according to the American Joint Committee on Staging of Cancer classification (AJCC 2002);
* measurable or evaluable disease
* no other primary tumors
* performance status (PS) of 0-2 according to the Eastern Cooperative Oncology Group scale (ECOG)
* adequate bone marrow, hepatic, renal and pulmonary function
* adequate nutritional status to tolerate protocol treatment and
* adequate mental status to follow instructions, keep appointments and provide written informed consent.
Exclusion Criteria:
* Secondary malignancies
* age\< 15 years
* ECOG PS 3-4
* Renal, hepatic, hematologic or pulmonary insufficiency
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.