The aim of this prospective randomized double-blind study is to compare the effectiveness of routine antiemetic prophylaxis for the prevention of intraoperative nausea and vomiting (IONV) in non-fasted parturients undergoing emergency cesarean section under spinal anesthesia.
Nausea and vomiting are common complications during cesarean delivery performed under spinal anesthesia and may negatively affect maternal comfort and perioperative safety. The incidence of these symptoms may be particularly increased in emergency cesarean sections involving non-fasted (full-stomach) parturients. This study compares two commonly used antiemetic strategies, namely 5-hydroxytryptamine-3 (5-HT3) receptor antagonists and dopamine receptor antagonists, to determine their relative effectiveness in preventing IONV during surgery.
The findings are expected to contribute to optimization of antiemetic prophylaxis protocols, improvement of maternal comfort, and reduction of perioperative complications associated with nausea and vomiting during emergency cesarean delivery.
Who can participate
Age range
18 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Pregnant women scheduled for emergency cesarean delivery under spinal anesthesia
* Non-fasted (full-stomach) parturients
* American Society of Anesthesiologists (ASA) physical status I-II
* Age ≥ 18 years
* Singleton pregnancy
* Ability to provide written informed consent
Exclusion Criteria:
* ASA physical status III or higher
* Refusal to participate
* Elective cesarean delivery (non-emergency cases)
* Preoperative antiemetic use within 24 hours before surgery
* Known allergy or contraindication to study drugs (ondansetron or metoclopramide)
* Pre-existing gastrointestinal disorders (e.g., severe GERD, gastroparesis, bowel obstruction)
* Psychiatric illness or current use of psychotropic medications
* Preoperative anemia (as defined by institutional threshold, e.g., Hb \< 10 g/dL)
* Intraoperative conversion to general anesthesia
* Massive intraoperative hemorrhage (\>1000-1500 mL or requiring transfusion, depending on your protocol definition)
* Intraoperative administration of additional sedative or antiemetic agents outside study protocol
* Multiple gestation pregnancies
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Incidence of Intraoperative Nausea and Vomiting Immediately After Fetal Delivery